Evaluation of susceptibility of Gram-positive pathogens from a tertiary care hospital in Singapore to a novel oxazolidinone, tedizolid, by a gradient diffusion method and broth microdilution.

We compared the in vitro antimicrobial activities of tedizolid and linezolid on the Sensititre broth microdilution system for Gram-positive cocci isolates (n=146) from skin and skin structure infections and bloodstream infections, bronchoalveolar lavage and sputum. These pathogens included 40 methicillin-resistant , 38 coagulase-negative staphylococci, 20 and 48 beta-haemolytic spp. Susceptibility was simultaneously determined for 48 vanA vancomycin-resistant enterococci isolates 2013-2016 from rectal swabs (23 and 25 , of which 4 were linezolid-non-susceptible).