Ara h 2-Specific IgE Presence Rather Than Its Function Is the Best Predictor of Mast Cell Activation in Children.

Background: Ara h 2-specific IgE (Arah2-sIgE) is an excellent serologic marker for peanut allergy. However, not all subjects with detectable Arah2-sIgE react clinically.

Objective: To assess the importance of functional characteristics of Arah2-sIgE for Ara h 2-induced mast cell activation.