Publications by authors named "Long Hei"
To establish an animal model of adjacent intervertebral disc degeneration by performing spinal fixation and fusion after percutaneous needle puncture and removal of the intervertebral disc or percutaneous needling of the vertebral body without removal of the intervertebral disc. We established a model of adjacent intervertebral disc degeneration after spinal fixation and fusion of rabbits maintained in upright feeding cages. Twenty-five healthy New Zealand rabbits were used.
View Article and Find Full Text PDFArticle Synopsis
- Bovine serum albumin nanoparticles loaded with isoniazid and rifampicin (INH-RFP-BSA-NPs) were created using a modified self-emulsion solvent diffusion method, resulting in particles that are smooth, spherical, and about 60.5 nm in diameter.
- Drug loading for isoniazid and rifampicin was high, with efficiencies of 19.8% and 20.1%, respectively, and entrapment rates reached 87.8% for isoniazid and 98.0% for rifampicin.
- The nanoparticles demonstrated sustained drug release, with 97.02% of isoniazid released over six days and complete release of rifampicin in five days.
Objective: To observe the effects of tauroursodeoxycholic acid (TUDCA) on nerve function after acute spinal cord injury (SCI) in rats, observe its effect on neuronal apoptosis and caspase-12 expression levels, and investigate the underlying mechanism.
Methods: We used a modified Allen's weight-drop trauma method to establish a rat acute SCI model. The rats were randomly divided into three groups: group A (sham surgery group), group B (DMSO control group) and group C (TUDCA treatment group), with 36 rats in each group.