This study aims to investigate the effects of Bushen Huoxue Decoction regulating adipose-derived stem cells(ADSCs)-exosomes(Exos) on the apoptosis of intervertebral disc nucleus pulposus cells(NPCs) and extracellular signal-regulated kinase(ERK) signaling pathway. Tert-butyl hydrogen peroxide(TBHP)-induced NPCs were divided into control, model, drug-containing serum, blank Exos, normal serum Exos, and drug-containing serum Exos groups. Cell viability and proliferation were examined by the CCK-8 assay and EdU staining, respectively.
View Article and Find Full Text PDFPathological vascular remodeling (VR) is characterized by structural and functional alterations in the vascular wall resulting from injury, which significantly contribute to the development of cardiovascular diseases (CVDs). The vascular wall consists primarily of endothelial cells (ECs), vascular smooth muscle cells (VSMCs), and adventitial fibroblasts (AFs), whose interactions are crucial for both the formation of the vascular system and the maintenance of mature blood vessels. Disruptions in the communication between these cell types have been implicated in the progression of VR.
View Article and Find Full Text PDFExpert Opin Drug Saf
December 2024
Background: Isavuconazole is a novel second-generation triazole antifungal agent.We conducted a retrospective investigation to analyze the occurrence of adverse events (AEs) associated with isavuconazole in real-world clinical use by data-mining self-reporting databases, aiming to provide comprehensive data for its safe and effective clinical application.
Research Design And Methods: All data obtained from the VigiBase, the EudraVigilance and the FAERS database.
The tea moth pest, is an economically important and highly damaging pest that drastically affects tea plant leaves. The chemical composition of its pheromone glands metabolites before and during calling period has not been reported yet. Therefore, the present study aimed at the metabolomic profiling of female moths' sex pheromones glands before and during calling period using gas chromatography time-of-flight mass spectrometry.
View Article and Find Full Text PDFDroplet-based digital PCR has emerged as a powerful platform for nucleic acid-based detection. However, the formation of droplet compartments and the subsequent amplification process in oil present significant drawbacks: instability under harsh thermal conditions, high background fluorescent noise inside droplets, and major difficulty in supporting multistep assays. Alternatively, droplets made of a hydrogel, or other advanced materials, have been adopted and demonstrate promising improvement over conventional droplet-based platforms.
View Article and Find Full Text PDFThe proliferation of Internet of Things (IoT) technology has significantly enhanced smart healthcare systems, enabling the collection and processing of vast healthcare datasets such as electronic medical records (EMRs) and remote health monitoring (RHM) data. However, this rapid expansion has also introduced critical challenges related to data security, privacy, and system reliability. To address these challenges, we propose a retrieval integrity verification and multi-system data interoperability mechanism for a Blockchain Oracle in smart healthcare with IoT Integration (RIVMD-BO).
View Article and Find Full Text PDFJ Colloid Interface Sci
December 2024
Triethylamine, an extensively used material in industrial organic synthesis, is hazardous to the human respiratory and nervous systems, but its accurate detection and prediction has been a long-standing challenge. Herein, a machine learning-motivated chemiresistive sensor that can predict ppm-level triethylamine is designed. The zero-dimensional (0D) bismuth vanadate (BiVO) nanoparticles were anchored on the surface of three-dimensional (3D) tungsten oxide (WO) architectures to form hierarchical BiVO/WO heterostructures, which demonstrates remarkable triethylamine-sensing performance such as high response of 21 (4 times higher than pristine WO) at optimal temperature of 190 °C, low detection limit of 57 ppb, long-term stability, reproducibility and good anti-interference property.
View Article and Find Full Text PDFMethamphetamine (METH) abuse is associated with significant neurotoxicity, high addiction potential, and behavioral abnormalities. Recent studies have identified a connection between the gut microbiota and METH-induced neurotoxicity and behavioral disorders. However, the underlying causal mechanisms linking the gut microbiota to METH pathophysiology remain largely unexplored.
View Article and Find Full Text PDFMumefural (MF), the primary functional ingredient of prunus mume extract that enhances blood fluidity, is produced by boiling the prunus mume juice for 24-48 h in a traditional one-step concentration process. Low MF yields and long processing time are two disadvantages of this process. This study introduced microwaves into the traditional one-step concentration process of prunus mume extract for increasing MF content.
View Article and Find Full Text PDFClin Mol Hepatol
December 2024
Background: Sarcomatoid hepatocellular carcinoma (HCC) is a rare histological subtype of HCC characterized by extremely poor prognosis; however, its molecular characterization has not been elucidated.
Methods: In this study, we conducted an integrated multiomics study of whole-exome sequencing, RNA-seq, spatial transcriptome, and immunohistochemical analyses of 28 paired sarcomatoid tumor components and conventional HCC components from 10 patients with sarcomatoid HCC, in order to identify frequently altered genes, infer the tumor subclonal architectures, track the genomic evolution, and delineate the transcriptional characteristics of sarcomatoid HCCs.
Results: Our results showed that the sarcomatoid HCCs had poor prognosis.
Background And Objectives: Randomized trials have proven the benefit of endovascular therapy (EVT) for acute large ischemic stroke. This study was to characterize the effect of time to treatment on benefit of EVT vs medical management (MM) among patients with large ischemic stroke.
Methods: This was a post hoc analysis of the Endovascular Therapy in Acute Anterior Circulation Large Vessel Occlusive Patients with a Large Infarct Core randomized trial.
Crit Rev Food Sci Nutr
December 2024
Intelligent packaging (also called smart packaging) has garnered significant attention for its ability to monitor food quality and spoilage during storage, without compromising packaging integrity. Natural pigments are being explored as sensors of food properties in these applications, but they are often chemically unstable, which limits their widespread utilization for this purpose. Therefore, enhancing pigment stability is imperative.
View Article and Find Full Text PDFFront Cell Neurosci
November 2024
The purpose of this study is to identify and analyze the application barriers and internal mechanisms of BIM technology in green building projects. It is found that BIM technology can effectively integrate information and optimize management, but its application still faces economic externalities and requires government intervention to promote its development. Through the analysis of five aspects of technology, economy, management, policy and environment, we identified 16 influencing factors and focused on nine key factors, such as insufficient technology maturity and high-cost issues.
View Article and Find Full Text PDFMercury-containing wastewater presents a significant environmental threat due to its high toxicity. Therefore, the urgent removal of mercury-laden wastewater is essential to protect ecosystems and public health. In this study, molybdenum disulfide (MoS) nanosheets modified with a silane coupling agent (designated as MS) were crosslinked with natural polymer chitosan (CS) rich in -NH and - OH groups to develop a highly efficient and environmentally friendly MoS-functionalized three-dimensional reticulated porous materials (denoted as MS/CTS) composite adsorbent.
View Article and Find Full Text PDFThe strong metal-support interactions (SMSI) can profoundly affect the electronic state of platinum (Pt) cocatalysts, which plays a dominant role for photocatalytic activity in the supported photocatalysts. However, the conventional Pt/g-CN photocatalysts usually shows negligible SMSI effect because of the lack of the reducible species. Herein, we demonstrate that the linker engineering of UiO66-type MOFs can effectively strengthen the SMSI and optimize the electron density of Pt nanoparticles on g-CN nanosheets.
View Article and Find Full Text PDFWe propose a programmable topological metasurface to integrate intelligent modulations of spatial and surface waves. A general design method is presented to design the programmable metasurface elements with PIN diodes. The surface waves can be controlled to propagate along the topological domain-wall interface by programming the C-symmetry elements, while the spatial waves are modulated by the patterns of C-symmetry elements.
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