Publications by authors named "Lone Aagaard"
Enterococcus faecalis is recognized as a multidrug-resistant nosocomial pathogen. The phenotypic basis for this is largely uncharacterized. The intrinsic efflux system of the antibiotic-susceptible E.
View Article and Find Full Text PDFReversal of resistance in microorganisms by help of non-antibiotics.
J Antimicrob Chemother
June 2007
Article Synopsis
- Scientists are studying different ways that bacteria and parasites resist drugs, especially focusing on how they pump drugs out of their cells.
- Some non-antibiotic drugs may actually help fight these infections and don't have as many harmful side effects, which makes them safer for people.
- These findings suggest that combining these new drugs with traditional antibiotics could be an effective way to tackle tough infections without causing additional problems for patients.
Our previous studies demonstrated that exposure of a bacterium to increasing concentrations of an antibiotic would increase resistance to that antibiotic as a consequence of activating efflux pumps. This study utilises the same approach; however, it employs the methicillin-resistant Staphylococcus aureus (MRSA) COL strain, which is highly resistant to oxacillin (OXA). MRSA COL was adapted to 3200 mg/L of OXA.
View Article and Find Full Text PDF