[Interferon alpha 2b for treatment of conjunctival melanoma: a case report].

A 71-year-old female patient with a status following multiple conjunctival excisions, histopathologically confirmed conjunctival melanoma (CMM) and also multiple therapy with mitomycin C presented with progressive conjunctival pigmentation. Treatment was carried out with local interferon α2b administration four or five times daily for several months. The lesion showed regression and lost pigmentation without any side effects.

Mobile phone use and risk of uveal melanoma: results of the risk factors for uveal melanoma case-control study.

We recently reported an increased risk of uveal melanoma among mobile phone users. Here, we present the results of a case-control study that assessed the association between mobile phone use and risk of uveal melanoma. We recruited 459 uveal melanoma case patients at the University of Duisburg-Essen and matched 455 case patients with 827 population control subjects, 133 with 180 ophthalmologist control subjects, and 187 with 187 sibling control subjects.

[Inflammatory juvenile conjunctival nevus (IJCN)].

Background: Pathologists may occasionally have difficulties in reliably assessing the dignity of tumour cells in histological sections, especially in nevi with junctional activity.

Patient History: This case history of a boy suffering from an inflammatory juvenile conjunctival nevus (IJCN) is reported with a follow-up period of 25 years. Seven years after first surgical treatment of a histologically proven nevus, a recurrent pigmented lesion within the former operation area aroused the suspicion of it being a malignant melanoma.

[Malignant conjunctival melanoma. Clinical review with recommendations for diagnosis, therapy and follow-up].

Background: Malignant conjunctival melanoma is a rare disease with an incidence of 0.03 - 0.08.

Long-term follow-up of patients with conjunctival melanoma.

Data from long-term follow-up examinations of patients with conjunctival melanoma are limited. A retrospective study of survival rates and local tumor relapse rates was performed on 85 patients initially treated between 1958 and 1993. Therapeutic procedures were local excision, local excision followed by brachytherapy, local excision combined with cryotherapy, and local excision followed by either irradiation or cryotherapy and adjuvant mitomycin C (MMC) application.

Cell proliferation activity in posterior uveal melanoma after Ru-106 brachytherapy: an EORTC ocular oncology group study.

Aim: To evaluate the cell proliferation activity in posterior uveal melanomas after Ru-106 brachytherapy.

Methods: Eyes containing choroidal or ciliary body melanoma from seven ocular oncology centres, which were enucleated after first being treated by Ru-106 brachytherapy and which had enough melanoma tissue to enable histological assessment, were included. The 57 eligible specimens were divided into a group of 44 eyes that were enucleated because of tumour regrowth, and a non-recurrent group of 13 eyes that were enucleated because of complications such as neovascular glaucoma.

[Intraocular involvement as initial symptoms of non-Hodgkin lymphoma].

Background: The diagnosis of a intraocular lymphoma is often delayed because of a symptomatic pseudouveitis.

Case Report: We report on a 68-year-old female patient, who was referred because of a tumor of the optic disk in her right eye and bilateral uveitis with secondary glaucoma. The painful blind right eye was enucleated.

Long-term follow-up of Ru-106/Rh-106 brachytherapy for posterior uveal melanoma.

Background: Currently available information about survival, local tumor control rates, secondary enucleation rates, and visual acuity following Ru-106/Rh-106 applicator therapy for choroidal and ciliochoroidal melanomas is limited in terms of duration of follow-up among surviving patients.

Methods: The authors performed a retrospective descriptive study of the rates of survival, local treatment failure, secondary enucleation, and visual acuity decrease in 140 patients (141 eyes) with choroidal or ciliochoroidal melanoma treated by Ru-106/Rh-106 applicator radiotherapy between 1964 and 1976. Median follow-up duration among surviving patients in this series was 17.

[Intraocular invasion of melanoma of the conjunctiva].

Background: The treatment of a localised conjunctival melanoma usually requires local excision combined with cryotherapy, brachytherapy and/or local chemotherapy.

Case Report: A 71 year old woman suffering from a conjunctival melanoma located at the limbus of her left eye was treated by local excision and cryotherapy. After this therapeutic procedure two recurrences occurred which had been again treated by excision and cryotherapy and finally brachytherapy.

[Mitomycin C in treatment of conjunctival melanoma and primary acquired melanosis].

Background: Since 1995 we have used Mitomycin C additionally in the treatment of conjunctival melanoma and primary acquired melanosis.

Methods: We report on the therapy results of 14 patients suffering from pigmented conjunctival lesions (malignant melanoma 9 and primary acquired melanosis 5). After local excision, cryotherapy or irradiation all patients received one eye drop Mitomycin C (0.

[Clinicopathologic study of 817 enucleations].

Methods: The clinical findings, the indications for enucleation and the histopathological diagnoses from 817 eyes from the University Eye Hospital in Leipzig, enucleated between 01/01/1980 and 31/12/1989 (433 males; 384 females), were analysed retrospectively to investigate, however, the therapeutic and diagnostic importance of enucleation to ophthalmological problems.

Results: The most frequent underlying ocular diseases were: intraocular tumour (47.7%), surgical disease [primary glaucoma, retinal detachment, cataract] (18.

[Morphologic changes in the lens epithelium in patients with age-induced cataract, radiation and steroid cataract and cataract following eye contusion].

The lens epithelium of the human eye plays a crucial role in the pathogenesis of primary and secondary cataract. Sixty hematoxylin-eosinstained lens epithelia were examined using a light microscope. Cell parameters were compared to one another in the various age groups of patients, between patients with secondary cataract (radiation cataract, steroid cataract and traumatic cataract) and patients with senile cataract, and between male and female patients.

[Metastasis of differentiated follicular thyroid carcinoma to the ciliary body].

A girl aged 20 years was suffering from a slowly growing tumor of the ciliary body of her left eye. The tumor was excised with iridocyclectomy supposed to be a melanoma. The histologic examination showed a well-differentiated follicular carcinoma of the thyroid gland.

Radiation effects on the optic nerve observed after brachytherapy of choroidal melanomas with 106Ru/106Rh plaques.

From 1966 to 1990 a total of 93 juxtapapillary choroidal melanomas were treated using 106Ru/106Rh plaques with a notch for the optic nerve. The choroidal melanoma was controlled after brachytherapy in 79 cases (85%). Fourteen eyes (15%) had to be enucleated because of tumor regrowth.

[Spontaneous growth inhibition in retinoblastoma].

Report on 8 cases with spontaneous arrest of retinoblastoma. The incidence was 3.2% which is approximately 1000 times more than in other malignant tumors.

[Results of treatment in malignant epithelial conjunctival tumors].

Tumors of the conjunctiva are rare, especially malignant epithelial tumors. Although these tumors grow very slowly and only exceptionally with local invasion, intensive treatment is necessary. We studied the results of combined treatment with excision and brachytherapy with strontium-90 in 30 patients with carcinoma in situ and squamous cell carcinoma.

[Static and dynamic infrared thermometry and thermography in malignant melanoma of the uvea and conjunctiva].

Background: Thermometry and -graphy prove asymmetries of the circulation. Contact-free thermometry of the cornea is applied to find out whether this method can contribute to differential diagnosis of ocular melanomas.

Materials And Methods: Under standardized conditions the temperature of the cornea was measured in 30 patients with malignant melanoma of the choroid and the conjunctiva and 35 healthy subjects.

[Effect of histological criteria (TpNM classification, degree of differentiation) on mortality of patients with retinoblastoma].

153 patients suffering from retinoblastoma and treated between 1960 and 1980 were analysed retrospectively. Median follow-up was 11.2 years.

[Local 133xenon clearance in the eye and comparative in vitro wash-out time determination in patients with monoclonal gammopathy].

The authors investigated the dependence of the local clearance of 133xenon to the viscosity of the blood. Increase of viscosity of blood compared with decrease of local clearance of 133xenon by patients with monoclonal gammopathy were demonstrated. It was also shown that using the Beta-part of radiation of 133xenon is sufficient for looking for wash-out-times of the anterior eye segment.

Treatment of juxtapapillary melanomas.

Thirty nine patients suffering from juxtapapillary choroidal melanoma were treated with Ru-106/Rh-106 beta-ray plaques. The tumoricidal dose was 100 Gy at the apex of the tumour within 7-14 days. Additional photocoagulation was performed in 12 eyes.