Extensive Disease and Exposure to Multiple Biologics Precolectomy Is Associated with Endoscopic Cuffitis Post-Ileal Pouch-Anal Anastomosis in Patients With Ulcerative Colitis.

Introduction: To better inform the risk of cuffitis in patients with ulcerative colitis (UC), we aimed to identify its occurrence and associated precolectomy factors in a large multicenter cohort of patients who underwent restorative proctocolectomy (RPC) with stapled ileal pouch-anal anastomosis (IPAA).

Methods: This study was a retrospective cohort analysis of individuals diagnosed with UC or indeterminate colitis who underwent RPC with IPAA for refractory disease or dysplasia at Mount Sinai Hospital or the University of Chicago followed by at least 1 pouchoscopy with report of the pouch-anal anastomosis. The primary outcome was cuffitis defined as ulceration of the cuff as reported in each pouchoscopy report.

Effect of Aerobic Exercise Training on Sleep and Core Temperature in Middle-Aged Women with Chronic Insomnia: A Randomized Controlled Trial.

Background: Exercise represents a viable non-pharmacological intervention to help treating insomnia but the interaction mechanisms between sleep and physical activity still remain poorly understood. The aim of this study was to investigate the effect of a aerobic exercise training intervention on sleep and core temperature.

Methods: Twenty-four adult women suffering from insomnia participated in this study.

Evaluation of Postoperative Infection Rates in 3084 Rhinoplasty Cases Using Antibiotic Soaks and/or Irrigations.

Postoperative infections after rhinoplasties are rare, yet devastating on patient outcomes. The literature reports an overall incidence of <2% with higher numbers seen in those requiring revision procedures. A retrospective chart review of rhinoplasty patients from 2002 to 2019 of the primary author (D.

Blinded Evaluation of Hyaluronic Acid Hand Filler Injections and Effects on First Impressions.

Background: The hands are the second most common body part visible after the face. In the aging hand, the dorsum loses volume, becomes uneven, veins become more prominent, and there is an increase in spots and wrinkles.

Objective: To determine the effects of large-particle hyaluronic acid filler injection into the dorsal hand on first impressions.

Modeling the effect of ascites-induced compression on ovarian cancer multicellular aggregates.

Epithelial ovarian cancer (EOC) is the most lethal gynecological malignancy. EOC dissemination is predominantly via direct extension of cells and multicellular aggregates (MCAs) into the peritoneal cavity, which adhere to and induce retraction of peritoneal mesothelium and proliferate in the submesothelial matrix to generate metastatic lesions. Metastasis is facilitated by the accumulation of malignant ascites (500 ml to >2 l), resulting in physical discomfort and abdominal distension, and leading to poor prognosis.

Cadherin composition and multicellular aggregate invasion in organotypic models of epithelial ovarian cancer intraperitoneal metastasis.

During epithelial ovarian cancer (EOC) progression, intraperitoneally disseminating tumor cells and multicellular aggregates (MCAs) present in ascites fluid adhere to the peritoneum and induce retraction of the peritoneal mesothelial monolayer prior to invasion of the collagen-rich submesothelial matrix and proliferation into macro-metastases. Clinical studies have shown heterogeneity among EOC metastatic units with respect to cadherin expression profiles and invasive behavior; however, the impact of distinct cadherin profiles on peritoneal anchoring of metastatic lesions remains poorly understood. In the current study, we demonstrate that metastasis-associated behaviors of ovarian cancer cells and MCAs are influenced by cellular cadherin composition.

Heterogeneous Cadherin Expression and Multicellular Aggregate Dynamics in Ovarian Cancer Dissemination.

Epithelial ovarian carcinoma spreads via shedding of cells and multicellular aggregates (MCAs) from the primary tumor into peritoneal cavity, with subsequent intraperitoneal tumor cell:mesothelial cell adhesion as a key early event in metastatic seeding. Evaluation of human tumor extracts and tissues confirms that well-differentiated ovarian tumors express abundant E-cadherin (Ecad), whereas advanced lesions exhibit upregulated N-cadherin (Ncad). Two expression patterns are observed: "mixed cadherin," in which distinct cells within the same tumor express either E- or Ncad, and "hybrid cadherin," wherein single tumor cell(s) simultaneously expresses both cadherins.

IL-17RA in Non-Hematopoietic Cells Controls CXCL-1 and 5 Critical to Recruit Neutrophils to the Lung of Mycobacteria-Infected Mice during the Adaptive Immune Response.

During chronic infection with Mycobacterium tuberculosis (Mtb), bacilli multiplication is constrained within lung granulomas until excessive inflammation destroys the lung. Neutrophils are recruited early and participate in granuloma formation, but excessive neutrophilia exacerbates the tuberculosis disease. Neutrophils thus appear as potential targets for therapeutic interventions, especially in patients for whom no antibiotic treatment is possible.

Mycobacteria-infected dendritic cells attract neutrophils that produce IL-10 and specifically shut down Th17 CD4 T cells through their IL-10 receptor.

Neutrophils participate in the control of mycobacterial infection both by directly eliminating bacilli and by interacting with macrophages and dendritic cells (DCs). Despite host defenses, slow-growing mycobacteria can persist in the host for decades, mostly inside macrophages and DCs, and eventually destroy tissues after exacerbated inflammation. IL-17A-driven neutrophil recruitment may participate in this process.

Teaching approaches in South African dental schools: direct restorative procedures.

Introduction: Worldwide the use of amalgam has declined and mercury-containing products are banned in several countries. National and international opinions on amalgam were recently discussed in journals. According to surveys, significant time is spent on the teaching of amalgam in American, Canadian, Irish and United Kingdom Dental Schools.

Effect of woven glass fibre reinforcement on the flexural strength of composites.

To measure and compare the flexural strength of composites reinforced with fibres, four groups of specimens (N = 10) were prepared from the combinations: Filtek Flow/Filtek Z250 and Esthet-X flow/Esthet-X dental composite. One group from each combination was reinforced with woven glass fibre (everStick net) and all the specimens subjected to three-point bend flexural testing. The mean and standard deviations for each test group were calculated and compared using one-way analysis of variance (ANOVA) followed by pairwise Bonferroni T-tests at a preset alpha of p < 0.

Microleakage of different amalgams bonded with dual cure resin cements.

Introduction: To reduce microleakage in high-copper amalgam restorations, bonding of amalgam was introduced.

Aim: This study compared the microleakage of admixed and spherical amalgams when bonded with different bonding intermediates under thermo- and non-thermocycling conditions.

Method And Materials: Class II butt-joint cavities were prepared in 200 extracted human molar teeth, and randomly divided into 5 groups.

Magnetic resonance imaging of neonatal encephalopathy at 4.7 tesla: initial experiences.

Objectives: The goals were to develop safe 4.7-T MRI examination protocols for newborn infants and to explore the advantages of this field strength in neonatal encephalopathy.

Methods: Nine ventilated newborn infants with moderate or severe encephalopathy were studied at 4.

[Ambulatory treatment of hemorrhoids].

DGHAL (Doppler Guided Hemorrhoid Arterial Ligation) represents a new approach to the treatment of internal hemorrhoids; it entails exact and selective ligation of the arteries supplying the piles (hemorrhoids). The intervention can be performed on ambulatory patients under local anaesthesia. An anoscope is used which incorporates a Doppler head.

Size of two-body weakly bound objects: short versus long range potentials.

The variation of the size of two-body objects is investigated, as the separation energy approaches zero, with both long range potentials and short range potentials having a repulsive core. It is shown that long range potentials can also give rise to very extended systems. Except for the l = 0 state, the asymptotic laws differ according to the range of the potential.

[Long-term results in ileo-anal reservoirs in the treatment of ulcero-hemorrhagic rectocolitis].

The authors report long term results of 53 ileo-anal anastomosis for ulcerative colitis. They used a "J" pouch technique with anastomosis to the anal canal after mucosectomy of the lower rectum. An upstream ileostomy should be created and left in place for two to three months.

Laparoscopic highly selective vagotomy.

Between February 1991 and August 1992, 35 patients underwent laparoscopic highly selective vagotomy (HSV) for recurrent duodenal ulcer disease. An antireflux procedure was also performed in 25 of these patients. There was no 30-day mortality and morbidity.

Colpocystodefecography.

Purpose: To assess, in one single procedure, a complete study of the female pelvis, including the Douglas pouch.

Methods: Colpocystodefecography (CCD) combines vaginal opacification, voiding cystography, and defecography. Three hundred examinations are reviewed.

Laparoscopic Nissen fundoplication: detailed analysis of 132 patients.

With the world-wide use of laparoscopy, new applications have been found, particularly in the field of esophageal and gastric surgery. From January 1991 through April 1992, 132 patients underwent laparoscopic Nissen fundoplication. The indication for laparoscopic intervention was symptomatic gastroesophageal reflux disease (GERD) not responding to medical treatment.