Neurobiology, psychotherapeutic interventions, and emerging therapies in addiction: a systematic review.

Substance use disorders (SUDs) represent a major challenge in psychiatric treatment, with significant relapse rates despite various psychotherapeutic interventions. This systematic review explores the neurobiological underpinnings of addiction and examines the efficacy of psychotherapies, such as Cognitive Behavioral Therapy (CBT), Eye Movement Desensitization and Reprocessing (EMDR), Mindfulness-Based Relapse Prevention (MBRP), and emerging therapies in treating SUDs. Additionally, the study assesses how emerging biomarkers and neuroimaging data could enhance therapeutic outcomes by guiding personalized treatments.

Infrared thermography and ulcer prevention in the high-risk diabetic foot: data from a single-blind multicentre controlled clinical trial.

Aim: To assess the usefulness of monthly thermography and standard foot care to reduce diabetic foot ulcer recurrence.

Methods: People with diabetes (n = 110), neuropathy and history of ≥ 1 foot ulcer participated in a single-blind multicentre clinical trial. Feet were imaged with a novel thermal imaging device (Diabetic Foot Ulcer Prevention System).

Between visit variability of thermal imaging of feet in people attending podiatric clinics with diabetic neuropathy at high risk of developing foot ulcers.

Objective: People with diabetic neuropathy who have previously ulcerated are at high risk of re-ulceration. They should regularly attend podiatry clinics for surveillance and routine protective podiatric treatment. It has been suggested that inflammation prior to skin breakdown shows up as a hotspot on a thermal image even in the absence of clinical signs.

Peripheral tissues reprogram CD8+ T cells for pathogenicity during graft-versus-host disease.

Graft-versus-host disease (GVHD) is a life-threatening complication of allogeneic stem cell transplantation induced by the influx of donor-derived effector T cells (TE) into peripheral tissues. Current treatment strategies rely on targeting systemic T cells; however, the precise location and nature of instructions that program TE to become pathogenic and trigger injury are unknown. We therefore used weighted gene coexpression network analysis to construct an unbiased spatial map of TE differentiation during the evolution of GVHD and identified wide variation in effector programs in mice and humans according to location.

Apoptosis in mesenchymal stromal cells induces in vivo recipient-mediated immunomodulation.

The immunosuppressive activity of mesenchymal stromal cells (MSCs) is well documented. However, the therapeutic benefit is completely unpredictable, thus raising concerns about MSC efficacy. One of the affecting factors is the unresolved conundrum that, despite being immunosuppressive, MSCs are undetectable after administration.

Find your ideal role.

RCN Bulletin Jobs Fairs have been helping nurses to develop their careers since 2009, with more than 28,000 visitors to Jobs Fair events around the country over the past seven years.

Raising the profile of mental health nursing.

Now an associate professor at Swansea University, Julia Terry was a senior lecturer when she applied for a fellowship with the National Institute for Health and Care Excellence (NICE), and is convinced this was a key factor in her promotion.

Backing public health will save money in long term.

Cuts to the public health budget have been condemned as illogical and short-sighted by nurses.

Improving the knowledge base in older people's care.

The UK has a rapidly ageing population, and the number of people aged over 75 is projected to double in the next 30 years. In November 2014, King's College London introduced the Older Person's Nurse Fellowship, a pioneering programme designed to give senior nurses the knowledge and skills to optimise quality of life for older people, and lead the way in transforming care and services. This article examines the fellowship programme, its aims and intended effect on practice.

Synthesis and Evaluation of a 2,11-Cembranoid-Inspired Library.

The 2,11-cembranoid family of natural products has been used as inspiration for the synthesis of a structurally simplified, functionally diverse library of octahydroisobenzofuran-based compounds designed to augment a typical medicinal chemistry library screen. Ring-closing metathesis, lactonisation and SmI2 -mediated methods were exemplified and applied to the installation of a third ring to mimic the nine-membered ring of the 2,11-cembranoids. The library was assessed for aqueous solubility and permeability, with a chemical-space analysis performed for comparison to the family of cembranoid natural products and a sample set of a screening library.

Evaluation of Convalescent Plasma for Ebola Virus Disease in Guinea.

Background: In the wake of the recent outbreak of Ebola virus disease (EVD) in several African countries, the World Health Organization prioritized the evaluation of treatment with convalescent plasma derived from patients who have recovered from the disease. We evaluated the safety and efficacy of convalescent plasma for the treatment of EVD in Guinea.

Methods: In this nonrandomized, comparative study, 99 patients of various ages (including pregnant women) with confirmed EVD received two consecutive transfusions of 200 to 250 ml of ABO-compatible convalescent plasma, with each unit of plasma obtained from a separate convalescent donor.

EpCAM based capture detects and recovers circulating tumor cells from all subtypes of breast cancer except claudin-low.

Purpose: The potential utility of circulating tumor cells (CTCs) as liquid biopsies is of great interest. We hypothesized that CTC capture using EpCAM based gating is feasible for most breast cancer subtypes.

Results: Cancer cells could be recovered from all intrinsic subtypes of breast cancer with IE/FACS, however, claudin-low cell lines showed very low capture rates compared to the four other groups (p = 0.

The caring touch.

If Catherine Malia had not become a nurse, she would like to have been a florist. As nurse consultant at St Gemma's Hospice in Leeds, her flower arranging skills have come in handy on more than one occasion.

Political influence.

SENIOR NURSES in Northern Ireland are to be trained in political influencing to help them understand better the political landscape of the country, and how they can help to shape policy on behalf of nurses and nursing.

Tackling dementia.

DISCHARGE PLANNING for patients with dementia can be difficult enough when arranging local services, so imagine trying to organise a care package for a patient being discharged to the US. This is exactly what leading dementia nurse Jeni Bell did when the daughter of a patient came to one of the cafés she runs to support the carers of patients with dementia at University Hospital Southampton NHS Foundation Trust.