Four Prenylflavone Derivatives with Antiplasmodial Activities from the Stem of Tephrosia purpurea subsp. leptostachya.

Four new flavones with modified prenyl groups, namely ()-5-hydroxytephrostachin (), purleptone (), ()-5-hydroxyanhydrotephrostachin (), and terpurlepflavone (), along with seven known compounds (-), were isolated from the CH₂Cl₂/MeOH (1:1) extract of the stem of subsp. , a widely used medicinal plant. Their structures were elucidated on the basis of NMR spectroscopic and mass spectrometric evidence.

Antiplasmodial prenylated flavanonols from Tephrosia subtriflora.

The CHCl/MeOH (1:1) extract of the aerial parts of Tephrosia subtriflora afforded a new flavanonol, named subtriflavanonol (1), along with the known flavanone spinoflavanone B, and the known flavanonols MS-II (2) and mundulinol. The structures were elucidated by the use of NMR spectroscopy and mass spectrometry. The absolute configuration of the flavanonols was determined based on quantum chemical ECD calculations.

Three Chalconoids and a Pterocarpene from the Roots of Tephrosia aequilata.

In our search for new antiplasmodial agents, the CH₂Cl₂/CH₃OH (1:1) extract of the roots of was investigated, and observed to cause 100% mortality of the chloroquine-sensitive (3D7) strain of at a 10 mg/mL concentration. From this extract three new chalconoids, -2',6'-dimethoxy-3',4'-(2'',2''-dimethyl)pyranoretrochalcone (, aequichalcone A), -2',6'-dimethoxy-3',4'-(2'',2''-dimethyl)pyranoretrochalcone (, aequichalcone B), 4''-ethoxy-3''-hydroxypraecansone B (, aequichalcone C) and a new pterocarpene, 3,4:8,9-dimethylenedioxy-6a,11a-pterocarpene (), along with seven known compounds were isolated. The purified compounds were characterized by NMR spectroscopic and mass spectrometric analyses.