Publications by authors named "Lois Hew"
NCS1 (Neuronal calcium sensor protein 1) encodes a highly conserved calcium binding protein abundantly expressed in neurons. It modulates intracellular calcium homeostasis, calcium-dependent signaling pathways as well as neuronal transmission and plasticity. Here, we generated a NCS1 knockout human induced pluripotent stem cell (hiPSC) line using CRISPR-Cas9 genome editing.
View Article and Find Full Text PDFBACKGROUNDPaclitaxel chemotherapy frequently induces dose-limiting sensory axonal polyneuropathy. Given that sensory symptoms are challenging to assess objectively in clinical practice, an easily accessible biomarker for chemotherapy-induced polyneuropathy (CIPN) holds the potential to improve early diagnosis. Here, we describe neurofilament light chain (NFL), a marker for neuroaxonal damage, as a translational surrogate marker for CIPN.
View Article and Find Full Text PDFArticle Synopsis
- Lck is a Src family kinase essential for T cell development and activation, playing a key role in TCR signaling through phosphorylation of the TCR/CD3 complex.
- The study reveals that free Lck has greater mobility and higher levels of activating phosphorylation compared to coreceptor-bound Lck, indicating different molecular properties of the two forms.
- Free Lck demonstrates increased kinase activity and promotes stronger T cell activation, while the coreceptor-Lck interaction operates independently of TCR activation, suggesting a regulatory mechanism for modulating T cell sensitivity.