Towards a mini-endoscope design with spatially selective excitation and imaging.

We describe a mini-endoscope design that uses a new type of electrically tunable liquid crystal lens array enabling the dynamic increase of spatial resolution by adjusting the working distance in various zones of interest over a relatively large field of view (FoV) without mechanical movement. The characterization of the system is performed by using uniform fluorescent films, fluorescent micro spheres and a tissue sample expressing the fluorescent calcium indicator GCaMP6s. Lateral resolution of up to 2 µm over the FoV between 300 µm - 400 µm is experimentally demonstrated.

Wavefront control capability in a modal lens with segmented circular peripheral electrodes.

We report the detailed investigation of the capability of an electrically tunable liquid crystal lens (TLCL) to dynamically generate various wavefront shapes. The TLCL operates in the modal-control mode with a peripheral circular electrode divided into eight individually controlled segments. This segmentation allows producing a rather rich set of influence functions.