Publications by authors named "Loic Jaffrelo"
Article Synopsis
- Scientists are trying to find a way to deliver helpful molecules directly to damaged parts of the body, especially in the gut.
- They created special particles that look like viruses (called VLP) to help carry these molecules into gut cells.
- Tests showed that these VLP can successfully enter gut cells and deliver a green protein, showing they could be a safe way to deliver medicine in the future.
We developed a functional selection system based on randomized genetic elements (GE) to identify potential regulators of hepatitis C virus (HCV) RNA translation, a process initiated by an internal ribosomal entry site (IRES). A retroviral HCV GE library was introduced into HepG2 cells, stably expressing the Herpes simplex virus thymidine kinase (HSV-TK) under the control of the HCV IRES. Cells that expressed transduced GEs inhibiting HSV-TK were selected via their resistance to ganciclovir.
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