Use of a vaccine strain of measles virus genetically engineered to produce carcinoembryonic antigen as a novel therapeutic agent against glioblastoma multiforme.

Despite the most aggressive medical and surgical treatments, glioblastoma multiforme remains incurable with a median survival of <1 year. We investigated the antitumor potential of a novel viral agent, an attenuated strain of measles virus (MV), derived from the Edmonston vaccine lineage, genetically engineered to produce carcinoembryonic antigen (CEA). CEA production as the virus replicates can serve as a marker of viral gene expression.

Management of intracranial infectious aneurysms: a series of 16 cases.

Objective: The purpose of this study was to better define the management of intracranial infectious aneurysms.

Methods: We present a retrospective review of the management of 16 patients with intracranial infectious aneurysms. The mean follow-up period was 86 months.

Stereotactic radiosurgery for idiopathic trigeminal neuralgia.

Object: Each year a greater number of patients with trigeminal neuralgia (TN) undergo radiosurgery, including a large number of patients who are candidates for microvascular decompression (MVD).

Methods: The case characteristics and outcomes of 117 consecutive patients who underwent radiosurgery were retrieved from a prospectively maintained database. The mean patient age was 67.

Far lateral extraforaminal lumbar synovial cyst: report of two cases.

Objective And Importance: We present two cases of a far lateral extraforaminal synovial cyst at the L5-S1 level of the spine. Neither case was diagnosed as a synovial cyst before surgery because of their atypical location. Only one other case of an extraforaminal synovial cyst, located at L4-L5, has been reported in the literature.

Natural history of tethered cord in patients with meningomyelocele.

Objective: The purpose of this study was to describe the natural history of tethered cord in patients who have undergone meningomyelocele repair.

Methods: We performed a retrospective review of 45 patients with a history of neonatal meningomyelocele repair who subsequently developed symptoms of tethered cord. Symptoms of tethered cord in this cohort consisted of the development of bladder spasticity or orthopedic foot deformity.