[Disturbances in the regulation of phospholipid metabolism of the whole liver, mitochondria and microsomes in acute thioacetamide poisoning and the influcence of silymarin].

In the whole liver of rats, pretreated with 4% polyvinylpyrrolidone solution, 24 h after i.p. application of 300 mg thioacetamide/kg body weight, an increase of total lipids, triglycerides and phospholipids is observed, in the mitochondrial fraction phospholipid concentrations are decreased.

[The effect of silybin-dihemisuccinate on regulation disorders in phospholipid metabolism in acute galactosamine intoxication in the rat].

1. 24 h after application of 900 mg D-galactosamine/kg body weight, an increase of total lipids, triglycerides, phosphatidyl-choline and phosphatidic acid concentrations, and also a decrease of total phospholipids and phosphatidylethanolamine can be determined in the whole rat liver. After administration of [1-14C]-palmitate, specific radioactivity of phosphatidyl-choline is diminished without alteration of specific radioactivity of other lipid fractions.