Single dose recombinant human erythropoietin reduces transforming growth factor beta in patients on chronic haemodialysis.

Short-term effects of recombinant human erythropoietin on serum levels of transforming growth factor beta-1, interleukin 1-alpha, interleukin 3, interferon gamma, and tumour necrosis factor alpha in patients with chronic renal failure on chronic haemodialysis were investigated. Recombinant human erythropoietin was applied subcutaneously in a dose of 75 IU/kg on 19 patients. Serum levels of transforming growth factor beta-1, interleukin 1-alpha, interleukin 3, interferon gamma, tumour necrosis factor alpha and erythropoietin, red blood cell parameters: red blood cell count, haemoglobin, haematocrit, and erythrocyte indices were determined before and after recombinant human erythropoietin single application.

[The relationship between resorption and the morphological changes in the gastric mucosa of rats after acute and chronic exposures to acetylsalicylic acid].

The effect of acute and chronic ASA administration on stomach and duodenal mucosa was studied on white male Wistar rats. ASA (250 mg/kg b.w.

[Plasma renin activity in tachistin-stimulated hypercalcemia and under the effect of chlorazine].

The aim of the present study was to elucidate the correlation between the Renin secretion and increased Plasma Calcium concentration and the role of Calmodulin in this process. Plasma Renin activity was determined radioimmunologically in 31 white rats, that were grouped as follows: group I - 7 controls loaded for 6 days perorally with 0.5 ml/200 g b.

Plasma aldosterone concentration during hypoxia, stimulated hyperglycaemia and when protein synthesis is blocked with actinomycin D.

In order to study the effect of various agents on aldosterone secretion, the aldosterone concentration was determined radioimmunologically in 41 rats divided in groups: group I--7 rats--controls; group II--11 rats loaded p.o. with 5.

[Acute-phase changes in ceruloplasmin after gamma-ray irradiation].

The change of ceruloplasmin level of blood serum of guinea-pigs was studied on the 12th h after irradiation with gamma-rays from 60Co, using doses of 1-10 Gy, power of the dose of 0.68 Gy/min. The enzyme level was raised by the increase of the irradiation dose as it was reduced by the dose of 10 Gy in comparison with the control animals.

[Erythropoietin activity in plasma after amantinine poisoning and hypoxia].

Determination of plasma erythropoietin activity was performed on highly sensitive to exogenous erythropoietin recipients-posthypoxic polycytemic mice. After submitting male white rats to a two-hour hypobaric hypoxia (0.42 atm.

Plasma erythropoietin activity in diabetes patients, studied by determining the 59Fe incorporation in posthypoxic polycythemic mice.

The plasma erythropoietin activity in diabetes patients was studied using methods for biological testing on posthypoxic polycythemic mice, based on the incorporation of 59Fe in the newly-formed red blood cells of the animals. The data are read on an automatic scintillation gamma-counter. Considerably higher erythropoietin activity of the plasma obtained from diabetics (p less than 0.

[Effect on erythropoietin production after inhibition of RNA synthesis by D-actinomycin and hyperglycemia].

Short-lasting hypobaric hypoxia was used in male white rats as a stimulus of erythropoietin synthesis (0.42 atm.).

Hypothalamic control of plasma renin activity.

The participation of the hypothalamus in the regulation of plasma renin activity (PRA) in rats was studied by applying electric stimulation to the supramammilar region (50 Hz, 1 ms, 150 muA), general hypoxia (90% N2 + 10% O2), and hypovolemia (peritoneal dialysis with 5.5% glucose) as stimuli of renin secretion. These techniques were combined with bilateral renal denervation and electrocoagulation in the supramammilar nuclei.