Physical activity and sedentary lifestyle in children with type 1 diabetes: a multicentre Italian study.

Background: Regular Physical Activity (RPA) is one of the cornerstones of Type 1 Diabetes (T1D) therapy, but conflicting results are reported in the literature.

Aim: To compare (RPA) and Sedentary Lifestyle (SL) among children with type 1 diabetes (T1D) and healthy peers.

Subjects And Methods: Seven Italian paediatric diabetes centres enrolled 129 children with T1D and 214 healthy peers who were interviewed by a telephone questionnaire on physical activity level, sedentary lifestyle and clinical data.

The ALBA project: an evaluation of needs, management, fears of Italian young patients with type 1 diabetes in a school setting and an evaluation of parents' and teachers' perceptions.

Objective: To determine how Italian parents and school personnel of 6-13-year-old children with type 1 diabetes (T1D) manage during school hours, including insulin administration, management of hypoglycemia, and glucagon use. A further aim was an investigation into the responsibilities and training of school personnel regarding diabetes.

Research Design And Methods: After an initial qualitative phase, semi-structured questionnaires were completed by a sample of parents and teachers.

Efficacy of nutrition counseling in young people with diabetes.

Aim: The aim of this study is to investigate if a non-prescriptive diet plan in young children with type 1 diabetes mellitus is unfavourable in comparison with classic prescriptive diet plan, paying particular attention to glycemic control, lipid profile and body mass index.

Methods: We carried out a longitudinal and 8-year retrospective study based on a well-defined cohort of children aged < 18 years with type 1 diabetes followed-up every three months from our Unit beginning from 1999 to 2007. The study included a total of 49 patients with type 1 diabetes aged 16-19 years, the mean duration of diabetes was 13 +/- 4 years.

Organization of paediatric diabetes units in Italy.

Aim of this work is to give a realistic picture of the medical care situation in Italy and to verify its congruence with ISPAD and SIEDP guidelines and the law. In Italy diabetes is recognized as a disease of great social interest by a state act. Sixteen years after its approval, all of the Italian Regions have received the law n.

Diabetes in childhood: are the laws obligations or resources? The Italian situation.

Two fundamental acts: "Provisions for the prevention and the cure of the diabetes mellitus" of 1987 and "Convention on the rights of the child, New York, 20 November 1989" of 1991, are a clear reference to the many laws promulgated in Italy protecting the special needs of children and adolescents with diabetes. In particular these acknowledge and emphasize the social value of the disease, the importance of the relationship with families and the infrequent need of hospital treatments. To give adequate answers to the need of self-management, it is essential to involve an integrated multidisciplinary team, adequately formed in order to supply an educational therapeutic intervention, based on medical aid and oriented on psycho pedagogy and social assistance.

Epoxide metabolite of quinine and inhibition of the multidrug resistance pump in human leukemic lymphoblasts.

Multidrug resistance (MDR) in neoplastic cells is usually due to decreased cellular retention of drugs such as vincristine or doxorubicin. An ATP-dependent drug efflux pump has been detected in MDR-1-phenotypic cells; inhibition of the MDR pump is probably the primary mechanism for reversal of MDR. Although quinine (SQ1) and quinidine are reversal agents and inhibitors of the MDR pump, the results from in vivo experiments and in vitro experiments with these diastereomers are contradictory.