Publications by authors named "Logeart D"
Article Synopsis
- - In 2022, France recorded 181,178 hospitalizations for heart failure (HF), yielding a prevalence rate of 2.6% among adults, while hospitalization rates were notably higher in socioeconomically deprived areas.
- - The overall hospital fatality rate for HF was 10.2%, with a significant increase to 34.0% within a year; however, only 20.1% of patients were admitted to rehabilitation within six months.
- - The findings highlight the need for improved cardiovascular prevention strategies and adaptations in healthcare services across different regions in France, emphasizing the importance of better adherence to treatment guidelines.
Article Synopsis
- This study evaluated the effectiveness of cardiac magnetic resonance (CMR) imaging compared to other diagnostic markers in predicting mortality in patients with AL cardiac amyloidosis (CA).
- Conducted on 176 patients with a median age of 68 years, the study found that high levels of NT-proBNP and troponin, along with low heart function measurements, were linked to increased mortality risk.
- Extracellular volume (ECV) from CMR emerged as a strong independent predictor of all-cause mortality and heart failure hospitalizations, suggesting it can enhance prognostic assessments beyond the established Mayo Clinic staging.
Rationale and design of the French Observatory of Acute Heart Failure (OFICA2).
Arch Cardiovasc Dis
September 2024
Background: Acute heart failure (AHF) is a leading cause of hospitalization and mortality - especially in patients aged≥65 years in high-income countries - and represents a high healthcare burden. In the past decade, the epidemiology and management of heart failure (HF) has changed, with the emergence of new medical and interventional therapeutics, but up-to-date real-life data are scarce.
Aims: The main objectives are to describe baseline characteristics (with an emphasis on lifestyle, cognitive status, HF knowledge and treatment adherence), management, and in-hospital and mid-term outcomes of AHF patients in France.
Background And Aims: Based on retrospective studies, the 2022 European guidelines changed the definition of post-capillary pulmonary hypertension (pcPH) in heart failure (HF) by lowering the level of mean pulmonary artery pressure (mPAP) and pulmonary vascular resistance (PVR). However, the impact of this definition and its prognostic value has never been evaluated prospectively.
Methods: Stable left HF patients with the need for right heart catheterization were enrolled from 2010 to 2018 and prospectively followed up in this multicentre study.
Rationale and design of the PACIFIC-PRESERVED (PhenomApping, ClassIFication and Innovation for Cardiac dysfunction in patients with heart failure and PRESERVED left ventricular ejection fraction) study.
Arch Cardiovasc Dis
May 2024
Background: Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous syndrome that is poorly defined, reflecting an incomplete understanding of its pathophysiology.
Aim: To redefine the phenotypic spectrum of HFpEF.
Methods: The PACIFIC-PRESERVED study is a prospective multicentre cohort study designed to perform multidimensional deep phenotyping of patients diagnosed with HFpEF (left ventricular ejection fraction≥50%), patients with heart failure with reduced ejection fraction (left ventricular ejection fraction≤40%) and subjects without overt heart failure (3:2:1 ratio).
Aims: The use of large medical or healthcare claims databases is very useful for population-based studies on the burden of heart failure (HF). Clinical characteristics and management of HF patients differ according to categories of left ventricular ejection fraction (LVEF), but this information is often missing in such databases. We aimed to develop and validate algorithms to identify LVEF in healthcare databases where the information is lacking.
View Article and Find Full Text PDFIn-hospital prognostic value of TAPSE/sPAP in patients hospitalized for acute heart failure.
Eur Heart J Cardiovasc Imaging
July 2024
Article Synopsis
- - The study investigated the use of the TAPSE/sPAP ratio, measured by echocardiography, to predict in-hospital major adverse cardiovascular events (MACEs) in patients hospitalized for acute heart failure (AHF) across multiple French hospitals.
- - A total of 333 patients were included, revealing that a TAPSE/sPAP ratio of less than 0.40 mm/mmHg was independently linked to a higher risk of in-hospital MACEs, which occurred in 15% of patients studied.
- - The findings suggest that early assessment of TAPSE/sPAP can improve risk stratification in AHF patients and may prompt closer monitoring and intervention strategies.
Article Synopsis
- - Natriuretic peptides like BNP and NT-proBNP are essential for diagnosing heart failure (HF) due to their accuracy, especially in cases of sudden shortness of breath, helping to distinguish cardiac issues from other causes.
- - Elevated levels of these peptides indicate heart failure, while normal levels can effectively exclude it; factors like age, kidney function, and obesity can affect their levels and should be considered in diagnosis.
- - For patients with chronic heart failure, measuring these peptides aids in monitoring the condition, adjusting treatment, and assessing prognosis, but it's important to stick to one specific biomarker to reduce confusion.
Article Synopsis
- Left ventricular remodeling (LVR) after a heart attack (myocardial infarction) can cause serious complications like heart failure and death; the study aims to identify negative LVR patterns 6 months post-MI and how they relate to patient outcomes.
- A multicenter analysis of 410 patients revealed significant increases in heart volume measurements, with around half showing concerning LV dilation, and 37% having a reduced ejection fraction at the 6-month mark.
- Predictive factors for adverse LVR included specific heart function metrics rather than standard clinical characteristics; there was a strong correlation between significant LV changes and increased risk for death or heart failure in the long term.
In heart failure patients with reduced ejection fraction, Sacubitril/valsartan (S/V) increased proBNP T71 glycosylation, which is regulated negatively by hypoxia via miR-30a . Using a cohort of 73 HFrEF patients who were transitioned from standard HF medication to S/V, we found that the increase in proBNP T71 glycosylation after S/V was associated with a decrease in cardiac hypoxia. We further found that plasma levels of K709-acteylated HIF1α, HIF-regulated and HIF-independent biomarkers also evolved consistently with a decrease in hypoxia.
View Article and Find Full Text PDFHeart failure (HF) is a major public health problem affecting millions of adults worldwide. HF with preserved ejection fraction, i.e.
View Article and Find Full Text PDFBackground: Both light-chain (AL) amyloidosis and transthyretin (ATTR) amyloidosis are types of cardiac amyloidosis (CA) that require accurate prognostic stratification to plan therapeutic strategies and follow-ups. Cardiac biomarkers, e.g.
View Article and Find Full Text PDFBackground: Cardiac magnetic resonance imaging may provide a non-invasive alternative to coronary angiography for differentiating between ischaemic and non-ischaemic cardiomyopathy in cases of unexplained reduced left ventricular ejection fraction.
Aim: The CAMAREC study aims to evaluate the diagnostic accuracy of cardiac magnetic resonance imaging in predicting significant coronary artery disease in patients with reduced left ventricular ejection fraction, using coronary angiography as the gold standard for comparison.
Methods: CAMAREC is a prospective cohort study of 406 patients in 10 centres with newly diagnosed, unexplained left ventricular ejection fraction ≤ 45%.
Exercise hypoxaemia in heart failure with preserved ejection fraction.
Eur J Heart Fail
September 2023
Article Synopsis
- The study aimed to assess the left atrioventricular coupling index (LACI) using cardiac CT as a tool to predict cardiovascular death in patients without known cardiovascular disease.
- Conducted on 1,444 patients over a median follow-up of 6.8 years, results showed that a higher LACI correlates with increased risks of cardiovascular and all-cause death.
- LACI ≥ 25% was identified as a significant predictor for cardiovascular death, demonstrating additional prognostic value beyond traditional risk factors and cardiac CT angiography findings.
Background: Elevated BNP and the N-terminal fragment of the proBNP (NT-proBNP) are hallmarks of heart failure (HF). Generally, both biomarkers parallel each other. In patients receiving sacubitril/valsartan, BNP remained stable while NT-proBNP decreased.
View Article and Find Full Text PDFAims: Cardiac amyloidosis (CA) is associated with an elevation of natriuretic peptides and troponins, predicting outcome. Nevertheless, the diagnostic yield of these biomarkers has not been extensively investigated. This study aimed to evaluate the diagnostic performance for CA of N-terminal pro-B-type natriuretic peptide (NT-proBNP) and high-sensitivity troponin T (hs-TnT).
View Article and Find Full Text PDFArticle Synopsis
- Heart failure (HF) registries often have incomplete follow-up data, while medicoadministrative databases contain reliable long-term data but provide less clinical detail, making their combination beneficial yet largely untested.
- A study aimed to evaluate the effectiveness of linking the FRESH HF registry with the French National Healthcare System database (SNDS) using a probabilistic algorithm to enhance data accuracy.
- Results indicated that a majority of patients could be matched (94.3% accuracy for deaths) and highlighted discrepancies in data between the two systems, such as higher hospitalization rates in the SNDS compared to the registry cohort.*
Background: Myocardial infarction (MI) induces a repair response that ultimately generates a stable fibrotic scar. Although the scar prevents cardiac rupture, an excessive profibrotic response impairs optimal recovery by promoting the development of noncontractile fibrotic areas. The mechanisms that lead to cardiac fibrosis are diverse and incompletely characterized.
View Article and Find Full Text PDFBackground: Recent studies have described a novel left atrioventricular coupling index (LACI), which had a better prognostic value in predicting cardiovascular events than individual left atrial (LA) or left ventricular (LV) variables.
Aims: To identify determinants of LACI and its 10-year annual change (ΔLACI), measured by cardiac magnetic resonance (CMR), and to better understand the variables governing this left atrioventricular coupling.
Methods: In the Multi-Ethnic Study of Atherosclerosis, 2112 study participants, free from cardiovascular disease at baseline, had LACI assessed by CMR imaging at baseline (LACI; 2000-2002) and 10 years later (2010-2012).
Background: Aside from the culprit plaque, the presence of vulnerable plaques in patients with acute coronary syndrome (ACS) may be associated with future cardiac events. A link between calcification and plaque rupture has been previously described.
Aim: To assess whether analysis of the calcium component of coronary plaques using CT angiography, coronary computed tomographic angiography (CCTA) can help to detect additional vulnerable plaques in patients with non-ST elevation myocardial infarction (NSTEMI).
Background: Sacubitril/valsartan (S/V) treatment is beneficial in patients with heart failure with reduced ejection fraction (HFrEF), but its mode of action remains elusive, although it involves the increase in ANP (atrial natriuretic peptide).
Methods: Combining mass spectrometry and enzymatic assay in the plasma of 73 HFrEF patients treated with S/V and controls, we deciphered proANP processing that converts proANP into 4 vasoactive peptides.
Results: We found that proANP processing is sequential and involved meprin B, ECE (endothelin-converting enzyme) 1, and ANPEP (aminopeptidase N).
Article Synopsis
- There is ongoing debate about the effectiveness of salt-restricted diets in managing heart failure, with current dietary guidelines lacking consistency and supporting evidence.
- The OFICSel observatory collected data from 2822 patients hospitalized for heart failure, examining the relationship between cardiologists' dietary recommendations and patients’ understanding and adherence to these diets.
- Findings reveal that while 90% of patients received a recommendation for a diet with less than 6g of salt per day, only 33% adhered to it, and restrictive diets increased the perceived burden on patients, indicating a need for more evidence-based dietary guidelines.
Article Synopsis
- There hasn't been much focus on how to manage the risks of blood clots and bleeding in people with a condition called systemic amyloidosis.
- Studies show that around 5-10% of patients with amyloidosis have issues with blood clots, especially if their hearts are affected, which can make their health worse.
- Common problems that increase the risk of clots include heart failure and a heart condition called atrial fibrillation, while the risk of bleeding can rise due to digestive problems and kidney issues.