Current approaches in CRISPR-Cas systems for diabetes.

In the face of advancements in health care and a shift towards healthy lifestyle, diabetes mellitus (DM) still presents as a global health challenge. This chapter explores recent advancements in the areas of genetic and molecular underpinnings of DM, addressing the revolutionary potential of CRISPR-based genome editing technologies. We delve into the multifaceted relationship between genes and molecular pathways contributing to both type1 and type 2 diabetes.

Ultra-Fast Moisture Sensor for Respiratory Cycle Monitoring and Non-Contact Sensing Applications.

As human-machine interface hardware advances, better sensors are required to detect signals from different stimuli. Among numerous technologies, humidity sensors are critical for applications across different sectors, including environmental monitoring, food production, agriculture, and healthcare. Current humidity sensors rely on materials that absorb moisture, which can take some time to equilibrate with the surrounding environment, thus slowing their temporal response and limiting their applications.

Solitary Osteochondroma in Uncommon Sites- A Rare Case Report.

Introduction: Osteochondroma is a bony lesion arising from the surface of the bone. It com-prises a large percentage of all benign bone tumors. A unique feature of this tumor is the conti-nuity of cortical and medullary components between the normal bony tissue and aberrant tissue of osteochondroma.

A finite source retrial queueing inventory system with stock dependent arrival and heterogeneous servers.

This article discusses a finite-source stock-dependent stochastic inventory system with multiple servers and a retrial facility. The system can store a maximum of S items, and the lifetime of each item is exponentially distributed. The primary customer arrives at the waiting hall from the finite source and receives service from multi-servers.

Aggressive Giant Cell Tumor of Proximal Tibia Treated with Resection and Arthrodesis using Limb Reconstruction System - A Case Report.

Introduction: Giant cell tumors (GCTs) are one of the most aggressive benign tumors of the bone. For tumors around the knee joint, excision with preservation of joint movement is preferred. Resection arthrodesis or an amputation might be necessary sometimes.

Radiative flow of cross ternary hybrid nanofluid ( ) in a Darcy Forchheimer porous medium over a stretching cylinder with entropy minimization.

Stretching cylinders play a crucial role in the plastic and metal extrusion processes. This current investigation is to examine the Darcy Forchheimer flow of Carboxymethyl cellulose /water-based tri-hybrid nanofluid through a stretching cylinder. A composite of ternary hybrid nanofluid containing , and with CMC-water-based fluid has been added to the Crossflow model.

Optimization of two-wheeler Bike engine among three different designs using design of experiments.

This research presents the results of a fin heat transfer study of three different models of the motorcycle engine. The objective of this study is to minimize the external body temperature because the optimum design will be found when the heat transfer rate is maximized. The study obtains the procurement of a balance between the outer boundary temperature due to convective heat transfer and air-cooled fin design.

Entropy optimization of lid-driven micropolar hybrid nanofluid flow in a partially porous hexagonal-shaped cavity with relevance to energy efficient storage processes.

Hydromagnetically associated heat convection can greatly enhance the performance of high-efficiency thermal appliances and renewable energy sources through an optimized design. This investigation examines the production of thermodynamic irreversibility and heat convection for a double lid-driven flow within a partially porous stratified hexagonal enclosure. The top and bottom-wall are moving in the opposite direction with an equal velocity U.

Challenges in Obtaining and Seeking Information Among Breast Cancer Survivors in an Asian Country: a Qualitative Study.

Breast cancer survivors on adjuvant endocrine therapy (AET) have distinct information-seeking experience compared to those in the diagnosis and intensive treatment phase. This study aimed to understand the challenges in obtaining and seeking information among Malaysian breast cancer survivors. We conducted semi-structured, one-to-one interviews among patients using AET from two hospitals and a local cancer organization.

Replacement of failed items in a two commodity retrial queueing-inventory system with multi-component demand and vacation interruption.

This study investigates a crucial aspect of inventory management, which is the process of replacing failed items. In dynamic commercial environments, it is essential to efficiently and strategically replace failed items to maintain operational efficiency and ensure profitability. We consider a two-commodity retrial queueing-inventory system with vacation interruption.

Modeling of two-stage anaerobic onsite wastewater sanitation system to predict effluent soluble chemical oxygen demand through machine learning.

The present research aims to predict effluent soluble chemical oxygen demand (SCOD) in anaerobic digestion (AD) process using machine-learning based approach. Anaerobic digestion is a highly sensitive process and depends upon several environmental and operational factors, such as temperature, flow, and load. Therefore, predicting output characteristics using modeling is important not only for process monitoring and control, but also to reduce the operating cost of the treatment plant.

Peristaltic transport of Sutterby nanofluid flow in an inclined tapered channel with an artificial neural network model and biomedical engineering application.

Modern energy systems are finding new applications for magnetohydrodynamic rheological bio-inspired pumping systems. The incorporation of the electrically conductive qualities of flowing liquids into the biological geometries, rheological behavior, and propulsion processes of these systems was a significant effort. Additional enhancements to transport properties are possible with the use of nanofluids.

Draft genome sequences of the strains isolated from estuary sediments.

Draft genome sequences of four strains of the were generated using nanopore technology. The size of the genome ranges from 4.2 to 4.

Entropy analysis on EMHD 3D micropolar tri-hybrid nanofluid flow of solar radiative slendering sheet by a machine learning algorithm.

The purpose of this paper is to analyze the heat transfer behavior of the electromagnetic 3D micropolar tri-hybrid nanofluid flow of a solar radiative slendering sheet with non-Fourier heat flux model. The conversion of solar radiation into thermal energy is an area of significant interest as the demand for renewable heat and power continues to grow. Due to their enhanced ability to promote heat transmission, nanofluids can significantly contribute to enhancing the efficiency of solar-thermal systems.

Genome editing for phage design and uses for therapeutic applications.

The over usage of antibiotics leads to antibiotic abuse which in turn eventually raises resistance mechanisms among wide range of pathogens. Due to lack of experimental data of efficacy of phages as potential antimicrobial and therapeutic agent and also more specific and cumbersome isolation process against specific pathogens makes it not so feasible technology to be looked as an alternative therapy. But, recent developments in genome editing techniques enables programmed nuclease enzymes that has effectively improvised our methodology to make accurate changes in the genomes of prokaryote as well as eukaryote cells.

Anterior Screw Fixation for Odontoid Fractures - A Case Series.

Introduction: Fractures of the odontoid process are common cervical spine injuries, accounting for 10-20% of all cervical spine fractures. Anterior screw fixation of odontoid fractures is an osteosynthetic technique that can give immediate stability and preserve normal mobility.

Case Series: The study was conducted in Government Mohan Kumaramangalam Medical college in the period 2017-2020.

Value-based decision-making network functional connectivity correlates with substance use and delay discounting behaviour among young adults.

Substance use disorders are characterized by reduced control over the quantity and frequency of psychoactive substance use and impairments in social and occupational functioning. They are associated with poor treatment compliance and high rates of relapse. Identification of neural susceptibility biomarkers that index risk for developing a substance use disorder can facilitate earlier identification and treatment.

Computational Analysis of Darcy-Forchheimer Flow of Cu/Al-AlO Hybrid Nanofluid in Water over a Heated Stretchable Plate with Nonlinear Radiation.

The aim of this study is to examine the Darcy-Forchheimer flow = of H2O-based Al-Al2O3/Cu-Al2O3 hybrid nanofluid past a heated stretchable plate including heat consumption/ generation and non-linear radiation impacts. The governing flow equations are formulated using the Naiver-Stokes equation. These flow equations are re-framed by using the befitted transformations.

Scrutinization of second law analysis and viscous dissipation on Reiner-RivlinNanofluid with the effect of bioconvection over a rotating disk.

In comparison to Newtonian fluids, non-Newtonian fluids have fascinating features in heat transportation. Here, newly type of Reiner-Rivlinnanoliquid flow over the revolving disk for viscous dissipation (VD) is being explored in a multiple-slip effect. The inclusion of gyrotactic microorganisms in the nanoliquid enhances the tendency of the nanoparticles.

Thermal Behavior of the Time-Dependent Radiative Flow of Water-Based CNTs/Au Nanoparticles Past a Riga Plate with Entropy Optimization and Multiple Slip Conditions.

This communication deliberates the time-reliant and Darcy-Forchheimer flow of water-based CNTs/gold nanoparticles past a Riga plate. In addition, nonlinear radiation, heat consumption and multiple slip conditions are considered. Entropy generation is computed through various flow parameters.

Investigation on Thermally Radiative Mixed Convective Flow of Carbon Nanotubes/ Nanofluid in Water Past a Stretching Plate with Joule Heating and Viscous Dissipation.

The nature of this prevailing inquisition is to scrutinize the repercussion of MHD mixed convective flow of CNTs/Al2O3 nanofluid in water past a heated stretchy plate with injection/suction, heat consumption and radiation. The Joule heating and viscous dissipation are included in our investigation. The Navier-Stokes equations are implemented to frame the governing flow expressions.