Intracellular signaling pathway in dendritic cells and antigen transport pathway in vivo mediated by an OVA@DDAB/PLGA nano-vaccine.

Background: Poly(D, L-lactic-co-glycolic acid) (PLGA) nanoparticles have potential applications as a vaccine adjuvant and delivery system due to its unique advantages as biodegradability and biocompatibility.

Experimental: We fabricated cationic solid lipid nanoparticles using PLGA and dimethyl-dioctadecyl-ammonium bromide (DDAB), followed by loading of model antigen OVA (antigen ovalbumin, OVA) to form an OVA@DDAB/PLGA nano-vaccine. And we investigated the intracellular signaling pathway in dendritic cells in vitro and antigen transport pathway and immune response in vivo mediated by an OVA@DDAB/PLGA nano-vaccine.

Cu-labeled daratumumab F(ab') fragment enables early visualization of CD38-positive lymphoma.

Purpose: Abnormal CD38 expression in some hematologic malignancies, including lymphoma, has made it a biomarker for targeted therapies. Daratumumab (Dara) is the first FDA-approved CD38-specific monoclonal antibody, enabling successfully immunoPET imaging over the past years. Radiolabeled Dara however has a long blood circulation and delayed tumor uptake which can limit its applications.

Harvesting V at the National Superconducting Cyclotron Laboratory.

As part of an effort to develop aqueous isotope harvesting techniques at radioactive beam facilities, V and a cocktail of primary- and secondary-beam ions created by the fragmentation reaction of a 160 MeV/nucleon Ni beam were stopped in an aqueous target cell. After collection, V was separated from the mixture of beam ions using cation-exchange chromatography. The extraction efficiency from the aqueous solution was (47.

Isotope harvesting with Hollow Fiber Supported Liquid Membrane (HFSLM).

The Facility for Rare Isotope Beams (FRIB) will generate many unique isotopes of scientific interest which are retained in the primary beam dump. This work uses Hollow Fiber Supported Liquid Membrane (HFSLM) for extraction of ultra-trace concentrations of short-lived radioisotopes from the large solution volumes present in the primary beam dump loop. Part per trillion levels of V were successfully recovered from an aqueous solution spiked with predicted concentrations of chemically similar species, with an extraction efficiency of 71% in 60 min.

Synthesis and targeting of gold-coated Lu-containing lanthanide phosphate nanoparticles-A potential theranostic agent for pulmonary metastatic disease.

Targeted radiotherapies maximize cytotoxicity to cancer cells. In this work, we describe the synthesis, characterization, and biodistribution of antibody conjugated gold-coated lanthanide phosphate nanoparticles containing Lu. [Lu]LuGd(PO)@Au@PEG@Ab nanoparticles combine the radiation resistance of crystalline lanthanide phosphate for stability, the magnetic properties of gadolinium for facile separations, and a gold coating that can be readily functionalized for the attachment of targeting moieties.

Systematic study of the structure-property relationships of branched hierarchical TiO2/ZnO nanostructures.

We report a simple and effective route for fabricating branched hierarchical nanostructures of TiO(2)/ZnO by combining electrospinning and the low-temperature hydrothermal growth technique. First, TiO(2) nanofibers were prepared by electrospinning polystyrene (PS)/titanium tetraisopropoxide (Ti(OiPr)(4)) solutions onto glass substrates followed by calcination at 500 °C. The electrospun TiO(2) nanofibers served as a 3D primary platform upon which the branched, highly uniform, and dense secondary ZnO nanorods were hydrothermally grown.