Three patients highlighting potential pitfalls in platelet refractory testing.

Background: Platelet-transfusion refractory (PR) patients do not achieve expected post-transfusion platelet counts. We investigate suspected PR patients with post-transfusion platelet counts, indirect platelet antibody screens (ind-PAS), Class I HLA antibody tests (HLA-Scr), and physical platelet crossmatch (PXM) studies.

Study Design And Methods: The three following cases describe possible pitfalls of laboratory tests used in PR workup and management.