Development and validation of a machine-learning algorithm to predict the relevance of scientific articles within the field of teratology.

The Dutch Teratology Information Service Lareb counsels healthcare professionals and patients about medication use during pregnancy and lactation. To keep the evidence up to date, employees perform a standardized weekly PubMed query where relevant literature is identified manually. We aimed to develop an accurate machine-learning algorithm to predict the relevance of PubMed entries, thereby reducing the labor-intensive task of manually screening the articles.

[Wish to conceive while using infliximab: considerations].

Background: Inflammatory bowel disease affects many women of childbearing potential. Women who wish to conceive face many uncertainties. Effects of their medications and their disease may interfere with normal pregnancy and development of the child.

Pregnancy outcome following maternal exposure to pregabalin may call for concern.

Objective: To investigate pregnancy outcomes following maternal use of pregabalin.

Methods: This multicenter, observational prospective cohort study compared pregnancy outcomes in women exposed to pregabalin with those of matched controls (not exposed to any medications known to be teratogenic or to any antiepileptic drugs). Teratology Information Services systematically collected data between 2004 and 2013.

[The Teratology Information Service: medicines during pregnancy and lactation].

Many women use medication during pregnancy. Both the healthcare professional and the pregnant woman often have many questions about the possible adverse effects of the medication that are not always answered in the product information. The Teratology Information Service (TIS), a part of the Netherlands Pharmacovigilance Centre Lareb, is a centre of expertise in the field of the safety of medication use and other external influences during spermatogenesis, pregnancy and lactation.

[Pregnancy after isotretinoin use].

Background: Acne is a common problem that is increasingly being effectively treated with isotretinoin, a highly teratogenic agent. According to the pregnancy prevention program, contraception should be used until at least one month after discontinuing the medication.

Case Description: A 29-year-old woman became pregnant shortly after discontinuing isotretinoin.