Inulin Dehydration to 5-HMF in Deep Eutectic Solvents Catalyzed by Acidic Ionic Liquids Under Mild Conditions.

Valorization of carbohydrate-rich biomass by conversion into industrially relevant products is at the forefront of research in sustainable chemistry. In this work, we studied the inulin conversion into 5-hydroxymethylfurfural, in deep eutectic solvents, in the presence of acidic task-specific ionic liquids as catalysts. We employed aliphatic and aromatic ionic liquids as catalysts, and choline chloride-based deep eutectic solvents bearing glycols or carboxylic acids, as solvents.

A Unique Case of 'in Situ' Bifluoride Triggered Formation of Supramolecular Organogels Using Isophthalamide Hydrogen Bond Donating Receptors.

A novel isopthalamide based receptor HL2 featuring two p-benzoic acid units has been synthesised and its anion binding properties analysed by H-NMR spectroscopy in DMSO-d/0.5 % HO. As expected, in the presence of tetrabutylammonium (TBA) fluoride the deprotonation of the carboxylic acid moieties was observed.

Normative percentile values for the TGMD-3 for Italian children aged 3-11+years.

Objectives: Sufficient gross motor skill proficiency is an essential prerequisite for the successful performance of sport-specific skills and physical activities. The Test of Gross Motor Development is the most common tool for assessing motor skills in paediatric populations, however, there is a lack of 'normative' data available against which children's scores can be compared. Normative data would enable the comparison of an individual's motor development to age-standardised norms.

Tranexamic acid: single topical application for femoral neck fractures treated with arthroplasty results in lowest blood loss.

Purpose: Tranexamic acid is widely accepted for hip fractures but there is no agreement about dose or application method and the use is still off label for hip fractures. The aim of our study was to find the best application method of tranexamic acid in patients with femoral neck fractures comparing total blood loss, hemoglobin and transfusion rate.

Methods: A retrospective single centre cohort study (level I trauma centre) with 2008 patients treated operatively for a proximal femur fracture between January 2016 and January 2022 was performed.

Types of Complications and Associated Factors in Patients Undergoing Permanent Cardiac Pacemaker Implantation: A Systematic Review.

Background: Permanent Pacemaker (PPM) implantation is essential in treating cardiac arrhythmias and conduction disorders, especially in patients with heart failure. Although PPM has been proven to improve quality of life and prolong life expectancy in patients with cardiac conduction disorders, post implantation complications still often occur.

Purpose: This study aimed to identify types of complications and associated predictors in patients undergoing PPM implantation.

A Systematic Review of the Potential of Cold Compresses Therapy: Strategy for Preventing Hematoma and Alleviating Pain in Post Cardiac Catheterization Patients.

Background: Patients still frequently report complications after cardiac catheterization procedures, such as hematoma and pain. These complications increase the length of stay and hospital costs. Several studies have determined cold compress therapy's effectiveness in preventing hematomas and reducing pain in patients after cardiac catheterization.

Impact of Sex on Clinical Outcomes of Tandem Occlusion in Acute Ischemic Stroke Patients Treated With Mechanical Thrombectomy. A Propensity-Matched Analysis.

Background: Although mechanical thrombectomy (MT) represents the standard of care for ischemic stroke due to large-vessel occlusion (LVO), the impact of sex on outcomes in tandem occlusions remains unclear. We investigated sex-based differences in outcomes after MT for tandem occlusions.

Methods: This multicenter observational study included consecutive patients with tandem occlusion treated with MT across three stroke centers (2021-2023).

Comparing achievability and reproducibility of pulsed wave doppler and tissue doppler myocardial performance index and spatiotemporal image correlation annular plane systolic excursion in the cardiac function assessment of normal pregnancies.

Objectives: Multiple techniques have been proposed for functional fetal cardiology, including pulsed-wave (PW) and tissue Doppler imaging (TDI), Myocardial Performance Index (MPI), annular plane systolic excursion (TAPSE/MAPSE) and spatiotemporal image correlation (STIC). We aimed to compare these techniques' achievability and reproducibility to determine their clinical utility for each cardiac side.

Methods: Uncomplicated pregnancies from 22 to 39 weeks were recruited and images and volumes stored for offline analysis.

Exploring Maternal Challenges: A Pilot Study of Pain, Fatigue, and Anxiety in Newborn Care Within Rooming-in Settings.

In the rooming-in system, mothers and their healthy newborns stay together for 24 h a day; however, many women in the early postpartum period often find it challenging to balance their recovery from childbirth with the demands of caring for their newborns. This study aims to investigate the need for postpartum women to entrust their newborns to medical staff for care, and the relationship of this need with perceived pain, fatigue, and anxiety. The study uses the Need to Entrust a Newborn under the Care of the Staff (NEN) scale and the Numerical Rating Scale (NRS) to assess participants' levels of pain, fatigue and anxiety.

Hemophagocytic Lymphohistiocytosis Due to Ehrlichiosis: A Case Series.

Background: Hemophagocytic lymphohistiocytosis (HLH) is an immunologic syndrome characterized by excessive inflammation and tissue injury due to uncontrolled activation of the phagocytic system. The underlying mechanism is a lack of downregulation of activated macrophages and lymphocytes by natural killer and T cells. Unfortunately, the diagnosis is often delayed or missed due to the rarity of the disease, decreased awareness, and clinical picture variability.

Enhanced Reaction Kinetics in Stationary Two-Phase Flow through Porous Media.

Understanding the interaction between multiphase flow and reactive transport in porous media is critical for many environmental and industrial applications. When a nonwetting immiscible phase is present within the pore space, it can remain immobile, which we call unsaturated flow, or move, resulting in multiphase flow. Previous studies under unsaturated flow conditions have shown that, for a given flow rate, the product of a mixing-driven reaction increases as wetting phase saturation decreases.

Mechanistic Investigation of the Ce(III) Chloride Photoredox Catalysis System: Understanding the Role of Alcohols as Additives.

Photocatalytic C-H activation is an emerging area of research. While cerium chloride photocatalysts have been extensively studied, the role of alcohol additives in these systems remains a subject of ongoing discussion. It was demonstrated that the photocatalyst [NEt][CeCl] () produces •Cl and added alcohols exhibit zero-order kinetics.

INTEGRATING RADIOLOGICAL IMAGING TECHNIQUES INTO ANATOMY EDUCATION: MEDICAL TRAINING ENHANCEMANT THROUGH EARLY CT AND MRI TEACHING.

Unlabelled: Brain morphology understanding is essential for radiologists, neurologists, and neurosurgeons. Historically, anatomical learning of brain relied on ex vivo specimens. Modern in vivo brain CT and MRI provide spatial, three-dimensional imaging capabilities crucial to help diagnose diseases, plan surgeries, and monitor treatment progress.

Prognostic serum biomarkers of synaptic, neuronal and glial injury in patients with acute ischemic stroke of the anterior circulation.

Background: We aimed to investigate the prognostic role of β-synuclein in comparison to that of neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) for predicting functional outcome after acute ischemic stroke (AIS).

Methods: We measured serum concentrations of β-synuclein, NfL and GFAP 24 h after hospital admission in 213 consecutive patients with moderate-to-severe AIS. We investigated the association between serum biomarkers and radiological/clinical characteristics, 3-months mortality and functional outcome on the modified Rankin Scale (mRS).

Rational Synthesis of Highly Stable Dithienopyrrole-Embedded BODIPYs Exhibiting Large Stokes Shift.

A series of dithienopyrrole (DTP) embedded BODIPYs were synthesized and structurally characterized. These BODIPYs have strong absorption in the green region and broad emission in the red region with a large Stokes shift ranging from 3100 to 4200 cm. Interestingly, all three BODIPYs show intramolecular charge transfer interaction (ICT).

Monitoring Addiction to Pregabalin in Northern Algeria by Using Hair Testing.

Pregabalin (PGB) is a novel gamma-aminobutyric acid analog that has been recently approved for the treatment of partial-onset seizures, neuropathic pain, and fibromyalgia. Although PGB presents a low potential for abuse in comparison to other scheduled drugs, the literature reports its potential misuse, especially among individuals with former or current drug addiction. The present study aimed to develop and validate a novel method for the determination of PGB in hair to perform a retrospective observational study on the misuse of this drug in a population of addicted subjects from Northern Algeria.

Unraveling the Molecular Basis for G-Quadruplex-Binders to ALS/FTD-Associated G4C2 Repeats of the C9orf72 Gene.

The most recurrent familial cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) is the presence of an abnormal number of intronic GGGGCC (GC) repetitions in the C9orf72 gene, which has been proposed to drive ALS/FTD pathogenesis. Recently, it has been shown that such GC repetitions can fold into G-quadruplex (G4) secondary structures. These G4s have been selectively stabilized by small-molecule binders, furnishing proof-of-principle that targeting these non-canonical nucleic acid sequences represents a novel and effective therapeutic strategy to tackle neurodegenerative disorders.

Tannins and copper sulphate as antimicrobial agents to prevent contamination of seedling culture for restoration purposes.

Seed-based restoration methods are increasingly recognized as a relevant tool contributing to halt and reverse the loss of seagrass meadows while providing genetic and evolutionary benefit for the conservation of these habitats. protocols aimed at maximizing the survival of plantlets obtained from seeds in cultivation systems are therefore required. Previous trials of seedling culture of , the dominant seagrass of the Mediterranean Sea, recorded up to 40% loss due to mould development.

Exploring Sex Differences in Outcomes of Dual Antiplatelet Therapy for Patients With Noncardioembolic Mild-to-Moderate Ischemic Stroke or High-Risk Transient Ischemic Attack: A Propensity-Matched Analysis of the READAPT Study Cohort.

Background: Sex may impact clinical outcomes in patients with stroke treated with dual antiplatelet therapy (DAPT). We aimed to investigate the sex differences in the short-term outcomes of DAPT within a real-world population of patients with noncardioembolic mild-to-moderate ischemic stroke or high-risk transient ischemic attack.

Methods: We performed a propensity score-matched analysis from a prospective multicentric cohort study (READAPT [Real-Life Study on Short-Term Dual Antiplatelet Treatment in Patients With Ischemic Stroke or Transient Ischemic Attack]) by including patients with noncardioembolic mild-to-moderate stroke (National Institutes of Health Stroke Scale score of 0-10) or high-risk transient ischemic attack (age, blood pressure, clinical features, duration of transient ischemic attack, presence of diabetes [ABCD] ≥4) who initiated DAPT within 48 hours of symptom onset.

Proteome Reprogramming and Acquired Stress Tolerance in Potato Cells Exposed to Acute or Stepwise Water Deficit.

Water deficit negatively impacts crop productivity and quality. Plants face these challenges by adjusting biological processes and molecular functions according to the intensity and duration of the stress. The cultivated potato (Solanum tuberosum) is considered sensitive to water deficit, thus breeding efforts are needed to enhance its resilience.

The Italian Perinatal Surveillance System SPItOSS: insights from Confidential Enquiries.

Background: An effective strategy to reduce perinatal mortality requires an active surveillance system. This includes monitoring cases, organizing multidisciplinary local audits, conducting Confidential Enquiries, identifying avoidable factors, and facilitating changes in the healthcare system. In 2017, the Italian Obstetric Surveillance System launched the SPItOSS pilot Perinatal Surveillance System.

Longitudinal evolution of physical activity type and eating and weight concerns among adolescents.

Purpose: To provide a prospective 2 year follow-up of a previously enrolled adolescent high school sample, regarding body image and eating concerns, and patterns of sports type and physical activity.

Methods: Sports type, weekly time devoted to it, and psychopathological self-reports (Eating Disorders Examination Questionnaire 6.0, Body Uneasiness Test, and Muscle Dysmorphia Disorder Inventory) were evaluated longitudinally in a general population sample enrolled in a previous study, testing prospective variations in an observational setting.