Non-rigid deformation to include subject-specific detail in musculoskeletal models of CP children with proximal femoral deformity and its effect on muscle and contact forces during gait.

To account for proximal femoral deformities in children with cerebral palsy (CP), subject-specific musculoskeletal models are needed. Non-rigid deformation (NRD) deforms generic onto personalized bone geometry and thereby transforms the muscle points. The goal of this study was to determine to what extent the models and simulation outcomes in CP patients differ when including subject-specific detail using NRD or Magnetic Resonance Imaging (MRI)-based models.

The role of altered proximal femoral geometry in impaired pelvis stability and hip control during CP gait: A simulation study.

Children with cerebral palsy (CP) often present aberrant hip geometry, more specifically increased femoral anteversion and neck-shaft angle. Furthermore, altered gait patterns are present within this population. This study analyzed the effect of aberrant femoral geometry, as present in subjects with CP, on the ability of muscles to control hip and knee joint kinematics.

Subject-specific geometrical detail rather than cost function formulation affects hip loading calculation.

This study assessed the relative importance of introducing an increasing level of medical image-based subject-specific detail in bone and muscle geometry in the musculoskeletal model, on calculated hip contact forces during gait. These forces were compared to introducing minimization of hip contact forces in the optimization criterion. With an increasing level of subject-specific detail, specifically MRI-based geometry and wrapping surfaces representing the hip capsule, hip contact forces decreased and were more comparable to contact forces measured using instrumented prostheses (average difference of 0.

Sensitivity of predicted muscle forces during gait to anatomical variability in musculotendon geometry.

Scaled generic musculoskeletal models are commonly used to drive dynamic simulations of motions. It is however, acknowledged that not accounting for variability in musculoskeletal geometry and musculotendon parameters may confound the simulation results, even when analysing control subjects. This study documents the three-dimensional anatomical variability of musculotendon origins and insertions of 33 lower limb muscles determined based on magnetic resonance imaging in six subjects.

Hip contact force in presence of aberrant bone geometry during normal and pathological gait.

Children with cerebral palsy (CP) often present aberrant hip geometry, specifically increased femoral anteversion and neck-shaft angle. Furthermore, altered gait patterns are present within this population. We analyzed the effect of aberrant femoral geometry, as present in CP subjects, on hip contact force (HCF) during pathological and normal gait.

Quantifying individual muscle contribution to three-dimensional reaching tasks.

We investigated the individual muscle contribution to arm motion to better understand the complex muscular coordination underlying three-dimensional (3D) reaching tasks of the upper limb (UL). The individual contributions of biceps, triceps, deltoid anterior, medius, posterior and pectoralis major to the control of specific degrees of freedom (DOFs) were examined: using a scaled musculoskeletal model, the muscle excitations that reproduce the kinematics were calculated using computed muscle control and a forward simulation was generated. During consequent perturbation analyses, the muscle excitation of selected muscles was instantaneously increased and the resulting effect on the specific DOF was studied to quantify the muscle contribution.