Publications by authors named "Lobo Fernando"

Peptides with antifungal activity have gained significant attention due to their potential therapeutic applications. In this study, we explore the use of pretrained protein models as feature extractors to develop predictive models for antifungal peptide activity. Various machine learning classifiers were trained and evaluated.

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Growth alterations have been described in patients operated on for oral clefts. The purpose of this work was to analyze the craniofacial and palate morphology and dimensions of young adults operated on for oral clefts in early childhood in Spain. Eighty-three patients from eight different hospitals were divided into four groups based on their type of cleft: cleft lip (CL, n = 6), unilateral cleft lip and palate (UCLP, n = 37), bilateral cleft lip and palate (BCLP, n = 16), and cleft palate only (CPO, n = 24).

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This article investigates the performance of multistart next ascent hillclimbing and well-known evolutionary algorithms incorporating diversity preservation techniques on instances of the multimodal problem generator. This generator induces a class of problems in the bitstring domain which is interesting to study from a theoretical perspective in the context of multimodal optimization, as it is a generalization of the classical OneMax and TwoMax functions for an arbitrary number of peaks. An average-case runtime analysis for multistart next ascent hillclimbing is presented for uniformly distributed equal-height instances of this class of problems.

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Introduction: The objective of this investigation was to evaluate the effects of high-intensity light-emitting diode (LED) light from a curing device on the retinas of Wistar rats.

Methods: Six male Wistar rats were used, and their ocular structures were the focus of this study. During the photostimulation of each animal, the right eye of the animal, considered the control sample, was covered with a removable polyvinyl chloride cap, and the contralateral eye, the experimental sample, was exposed to high-intensity LED light, 3200 mW/cm (VALO Ortho; Ultradent Products, South Jordan, Utah) for 144 seconds from a distance of 30 cm.

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This paper describes an ongoing research project which explores the design and use of inexpensive robotics, artificial intelligence techniques, and human-computer interaction methods, to enrich assisted living environments. Such environments provide help to the inhabitants of a home or office, assisting them to perform daily activities, helping them to socialize and interact with others, and to provide enhanced levels of security and safeness. We present the development of an inexpensive robotic solution to help people with disabilities and/or older adults to perform their daily activities.

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Tamoxifen is the most widely used selective modulator of estrogen receptors (SERM) and the first strategy as coadjuvant therapy for the treatment of estrogen-receptor (ER) positive breast cancer worldwide. In spite of such success, tamoxifen is not devoid of undesirable effects, the most life-threatening reported so far affecting uterine tissues. Indeed, tamoxifen treatment is discouraged in women under risk of uterine cancers.

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Only few published studies that describe the neuroanatomy of lizards. Here, we describe the neuroanatomy of several Iguanian species belonging to three families (species of Liolaemus and Phymaturus belonging to Liolaemidae, Tropidurus and Stenocercus as representatives of Tropiduridae, and Diplolaemus as a representative of Leiosauridae). Based on Sudan Black B staining and conventional dissections, the neuroanatomy of the lumbosacral region is described.

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Background: Drinking water is recommended before and after exercise to avoid dehydration. However, water ingestion may mitigate or prevent postexercise hypotension. This study investigated the effects of intentional hydration on postaerobic exercise hemodynamics and autonomic modulation.

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The northernmost distributed group of lizards belonging to occurs in rocky outcrops of the Puna region between 3600-4200 m in Argentina. In a recent phylogenetic study based on morphological and genetic information, the monophyly of this small lineage was corroborated. This group is formed by , , , and a population of uncertain taxonomic status until the present study.

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In reptiles, many lipid reserve structures were recognized, and different patterns of storage and utilization of lipids have been identified. In this study, a population of Liolaemus koslowskyi was studied to analyze the diversity and functioning of the lipid reserve structures. The specific objectives were to identify the main lipid reserve structures, and to describe their seasonal patterns; to study sexual and seasonal variations of the reserve structures; and to analyze the relation between seasonal patterns of such reserves with the sexual cycle and other biological aspects.

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O-Ethylation of phthalides with Meerwein's reagent followed by reaction of the ensuing salts with pyrrole, results in the formation of 5-alkoxy-5-phenyl dipyrromethane derivatives, which function as ready precursors of ortho-substituted 8-aryl BODIPY derivatives by reaction with borontrifluoride etherate, an overall process that can be carried out in a one-pot operation.

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Background: Autologous breast reconstruction has become a progressively more popular method of breast reconstruction. A wide variety of perforator flaps have been described and subsequently refined to decrease donor-site morbidity. Recently, the lumbar artery perforator (LAP) flap has been reported as an option for autologous breast reconstruction.

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Unsaturated carbohydrate derivatives are useful intermediates in synthetic transformations leading to a variety of compounds. The aim of this review is to highlight the rich chemistry of ∆-2,3 unsaturated pyranosides, emphasizing the variety of transformations that have been carried out in these substrates during the last decade.

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Novel substrates that combine dicobalt hexacarbonyl propargyl (Nicholas) and pyranose-derived allylic (Ferrier) cations have been generated by treatment of hexacarbonyldicobalt (C-1)-alkynyl glycals with BF3 (.) Et2 O. The study of these cations has resulted in the discovery of novel reaction pathways that have shown to be associated to the nature of O-6 substituent in the starting alkynyl glycals.

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Introduction And Objective: Many designs of prostheses are available for middle ear surgery. In this study we propose a design for a new prosthesis, which optimises mechanical performance in the human middle ear and improves some deficiencies in the prostheses currently available. Our objective was to design and assess the theoretical acoustic-mechanical behaviour of this new total ossicular replacement prosthesis.

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Oplurus bibronii was a species described more than 160 years ago from the highlands of Ovalle, Chile. The species was earlier synonymized with Phymaturus palluma and since then its taxonomic status has not been re-examined. In February of 2011, we were successful in capturing specimens of Phymaturus in the highlands of Ovalle and additionally we examined high quality digital pictures of the type series of O.

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As a result of several field trips and studies of collections of Phymaturus samples from Andean areas of central western Argentina (San Juan province), we discovered two populations that exhibit a particular character combination not seen in other species formally recognized in the literature. Based on a detailed analysis of an extended list of morphological characters (93), including scalation, color pattern, gular and nuchal folds, precloacal pores, and morphometric data, we conclude that these populations represent independent lineages that deserve to be considered as new species. According to the most recent revision of the genus and considering the descriptions made in another recent contribution, the taxonomic composition of the genus was increased to 38 species.

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Pyranosidic allylic (Ferrier) cations that share dicobalt hexacarbonyl propargyl (Nicholas) stabilization at C-1 display a remarkable reactivity leading to either substituted oxepanes or 3-C-branched pyranosides, depending on the substituent at O-6.

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Introduction And Objectives: The cochlea has traditionally been considered as the first frequency selection filter in the auditory pathway due to the contraction of its external ciliated cells. Yet, much evidence has emerged from work carried out during experiments with animals, some of which is anatomical (connections between the auditory pathway and motor nuclei of the middle ear muscles) and other physiological, which indicates that the middle ear might be the first filter through which specific sounds from noisy environments may initially be isolated.

Methods: In cooperation with the Department of Mechanical Engineering of the Technical School of Industrial Engineering at the University of Valladolid (UVa) we have developed and refined a new admittance meter capable of evaluating changes in impedance that occur in the human middle ear depending on frequency.

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Many traits of the skull of ceratophryines are related to the capture of large prey independently of aquatic or terrestrial feeding. Herein, detailed descriptions of the development of hyoid skeleton and the anatomy of muscles responsible for hyoid and tongue movements in Lepidobatrachus laevis and L. llanensis are provided and compared with those of other neobatrachians.

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