Prediction of Solution Behavior via Calorimetric Measurements Allows for Detailed Elucidation of Polyoxometalate Transformation.

The solution behavior of a polyoxometalate cluster, LiNa-UPp (LiNa[(UOO)(PO)]) that consists of 24 uranyl ions, peroxide groups, and 12 pyrophosphate linkers, was successfully predicted based on new thermodynamic results using a calorimetric method recently described for uranyl peroxide nanoclusters (UPCs), molybdenum blues, and molybdenum browns. The breakdown of LiNa-UPp and formation of U (Li[UOOOH]) was monitored via Raman spectroscopy using a custom heating apparatus. A combination of analytical techniques confirmed the simultaneous existence of UPp and U midway through the conversion process and U as the single end product.

Incidence of prostate cancer in Eritrea: Data from the National Health Laboratory, Orotta Referral Hospital and Sembel Hospital 2011-2018.

Introduction: Up-to-date statistics on prostate cancer incidence and causative risk factors are essential for the primary prevention of this disease. However, the incidence of Prostate cancer (ICD-10 code C61) (PCa), or cancers in general, are poorly documented in Eritrea. This study analyses the data available to produce an estimate of the incidence of PCa in Eritrea.

Incidence of Breast Cancer in Eritrea: A Retrospective Study from 2011 to 2017.

In Africa, breast cancer closely compares with cervical cancer as the most common malignancy affecting women and the incidence rates appear to be rising. Eritrea is experiencing a growing breast cancer problem, but little is presently known on tumor patterns, breast cancer epidemiology, and risk factors. The main objective of this study is to provide baseline data on breast cancer incidence in both sexes in Eritrea.

In situ Raman spectroscopy of uranyl peroxide nanoscale cage clusters under hydrothermal conditions.

Aqueous solutions containing the nanoscale uranyl peroxide cage clusters U, [(UO)(O)(OH)], and UOx, [{(UO)(O)}(CO)], were monitored by in situ Raman spectroscopy during stepwise heating to 180 °C. In solutions containing U, clusters persist to 120 °C, although conversion of U to U, [(UO)(O)(OH)], occurs above 100 °C. UOx persisted in solutions heated to 150 °C, although partial conversion to smaller uranyl peroxide clusters species was observed beginning at 100 °C.

Transformation of Uranyl Peroxide Studtite, [(UO)(O)(HO)](HO), to Soluble Nanoscale Cage Clusters.

The dissolution behavior of uranyl peroxide studtite, [(UO)(O)(HO)](HO), was examined under a wide range of alkaline aqueous environments with and without the addition of hydrogen peroxide. In the absence of added HO, studtite dissolved in aqueous solutions with a tetraethylammonium hydroxide to uranium molar ratio greater than 0.5, and the resulting species in solution characterized by Raman spectroscopy and electrospray ionization mass spectrometry (ESI-MS) is the uranyl peroxide nanocluster U, [(UO)(O)(OH)].

Uranyl Peroxide Cage Cluster Solubility in Water and the Role of the Electrical Double Layer.

Uranium concentrations as high as 2.94 × 10 parts per million (1.82 mol of U/1 kg of HO) occur in water containing nanoscale uranyl cage clusters.

Structure and Reactivity of X-ray Amorphous Uranyl Peroxide, U2O7.

Recent accidents resulting in worker injury and radioactive contamination occurred due to pressurization of uranium yellowcake drums produced in the western U.S.A.

Spectrum of KIT/PDGFRA/BRAF mutations and Phosphatidylinositol-3-Kinase pathway gene alterations in gastrointestinal stromal tumors (GIST).

Pathogenetic pathways of gastrointestinal stromal tumors (GIST) lacking mutations in KIT and PDGFRA (∼15%) are still poorly studied. Nearly nothing is known about PI3K alterations in GISTs and only a few GISTs with BRAF mutations have been reported. BRAF mutations (V600E) were found in 3/87 tumors (3.

Sudden elevation of liver enzymes in a 64-year-old patient: a case report.

Eradication of Helicobacter pylori usually consists of a 7-day course of triple therapy including metronidazole or amoxicillin plus clarithromycin plus a proton pump inhibitor. We report about a rare adverse event of Hp eradication in a patient with moderate chronic and moderate active pangastritis. Shortly after the end of treatment cholestatic hepatitis occurred which was most likely related to clarithromycin, perhaps enhanced by amoxicillin.

Prevalence and origin of amyloid in kidney biopsies.

We aimed to reassess renal amyloidosis in kidney biopsies with a focus on possibly misclassified or unclassified cases and changes in the prevalence of different amyloid types. Two hundred thirty-three kidney biopsies obtained from 231 patients diagnosed with amyloid during the period from 1990 to 2007 years were included in this retrospective study. Amyloid was identified by Congo red staining and polarization microscopy.

Omega-3 fatty acids alleviate chemically induced acute hepatitis by suppression of cytokines.

Unlabelled: Cytokines such as tumor necrosis factor alpha (TNF-alpha) are key factors in liver inflammation. Supplementation with essential omega-3 polyunsaturated fatty acids (n-3 PUFA) has been demonstrated to lower TNF-alpha and IL-1 production in mononuclear cells. An inflammation-dampening effect has been observed with increased omega-3 fatty acid supplementation in several inflammatory diseases.

[Prolonged remission after immunotherapy of a previously refractory peripheral T-cell non-Hodgkin lymphoma].

History And Admission Findings: A 54-year-old woman in good condition was admitted because of a rapidly growing tumor in the right groin with skin infiltration. There were no B-symptoms and no increased susceptibility to infections.

Investigations: Histology revealed a peripheral T cell non-Hodgkin lymphoma (NHL).

[L-arginine administration improves mucosal structure in the early phase of reperfusion of small intestine transplants].

L-arginine and molsidomine application prior to reperfusion significantly reduced the preservation and reperfusion-related injury after small bowel transplantation. The architecture of the mucosa was best preserved after treatment with L-arginine and methylprednisolone. The macroscopic appearance of the mucosa was improved (less watery and less thin than after reperfusion of non-treated recipients).

Epstein-Barr virus DNA and epithelial markers in nasopharyngeal carcinoma.

Nasopharyngeal carcinoma (NPC) belongs to the most common malignant tumours in certain parts of the world, e.g. South-East Asia.

Preoperative evaluation of malignant liver tumors: comparison of unenhanced and SPIO (Resovist)-enhanced MR imaging with biphasic CTAP and intraoperative US.

The purpose of this study was to evaluate the diagnostic efficacy of iron-oxide-enhanced MRI vs CT during arterial portography (CTAP) and intraoperative ultrasound (IOUS) in detection of liver neoplasms. Seventeen patients with malignant focal liver lesions (liver metastases, n=7), hepatocellular carcinomas (HCC, n=9), and cholangiocellular carcinoma (CCC, n=1) underwent presurgical Resovist-enhanced MRI and CTAP. Two independent observers (A and B) assessed the blinded images of unenhanced and iron-oxide-enhanced MRI vs CTAP for the presence, number, and location of the liver lesions.

Distinct enzyme profiles in patients with cryptogenic cirrhosis reflect heterogeneous causes with different outcomes after liver transplantation (OLT): a long-term documentation before and after OLT.

Background: Sound information is lacking about the clinical presentation of cryptogenic cirrhosis and its outcome after orthotopic liver transplantation (OLT).

Methods: Among 856 patients who have been transplanted at our center, 40 patients had no evidence of any known etiologies and were therefore defined as suffering from cryptogenic cirrhosis. Their median follow-up period before OLT was 78 months (range, 1-264), and after OLT 97 months (range, 1-132).

Epstein-Barr virus DNA, intermediate filaments and epithelial membrane antigen in nasopharyngeal carcinoma.

The aim of this study was to investigate the expression of intermediate filaments (cytokeratin, vimentin), epithelial membrane antigen (EMA) and the presence of Epstein-Barr virus (EBV) DNA in undifferentiated nasopharyngeal carcinoma (NPC). A high incidence of nuclear signals in NPC was found in primaries and regional lymph node metastases (70%), using 35S-labelled probes of EBV plasmids for in-situ hybridization. Keratinizing squamous cell carcinomas were EBV-negative.

Extended resections for hilar cholangiocarcinoma.

Objective: To evaluate different strategies for extended resections of hilar cholangiocarcinomas on radicality and survival.

Summary Background Data: Surgical resection of hilar cholangiocarcinoma is the only potentially curative treatment. Resection of central bile duct carcinomas, however, cannot always comply with the general principles of surgical oncology to achieve wide tumor-free margins with no-touch techniques.

Severe panarteritis associated with drug abuse.

A case of panarteritis with purpura fulminans, mononeuritis multiplex, gastrointestinal manifestation and presumably cardiac involvement in a previously healthy 22-year-old man with a history of drug abuse including cocaine, cannabinoids and methamphetamines is described. Histopathological examination of the gut led to the diagnosis of panarteritis without immune deposits. Antineutrophil antibodies were negative.