Publications by authors named "Lobaina Abozaid"
Objective: Gastrointestinal stromal tumor (GIST) is the most common type of mesenchymal tumor accounting for 2.2% of all malignant gastric tumors. Mesenchymal stem cells (MSCs) play crucial roles in gastric carcinogenesis.
View Article and Find Full Text PDFObjective: In spite of great advance in the management of hepatocellular carcinoma (HCC), the prognostic factors are still obviously not understood. The role of tumor budding (TB) and tumor-infiltrating lymphocytes (TILs) in HCC as pathological parameters affecting prognosis stands principally unknown.
Methods: Seventy-four surgical resection pathology specimens of HCC patients were used.
Article Synopsis
- - NHMH is a benign reactive condition marked by an increase in histiocytic and scattered mesothelial cells, presented here in a 56-year-old HIV-positive male who had swelling and nodules in the greater omentum.
- - The patient was found to have an abnormal CD4/CD8 ratio and underwent surgery, with biopsies confirming the diagnosis through histopathological examination and immunohistochemical staining.
- - This case is notable for being the first report of NHMH in an HIV-positive patient, highlighting its potential to appear malignant on imaging, underscoring the need for accurate diagnosis to avoid incorrect treatment.
Aberrant activation of the NLRP3 inflammasome is recognized to induce a chronic inflammatory response in the liver, ultimately leading to hepatic fibrosis. HSP90 is suggested to regulate NLRP3 activation and its downstream signaling. This study is the first to explore the potential therapeutic role of pimitespib in mitigating liver fibrosis in rats.
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