Rapid, systematic updating of movement by accumulated decision evidence.

Acting in the natural world requires not only deciding among multiple options but also converting decisions into motor commands. How the dynamics of decision formation influence the fine kinematics of response movement remains, however, poorly understood. Here we investigate how the accumulation of decision evidence shapes the response orienting trajectories in a task where freely-moving rats combine prior expectations and auditory information to select between two possible options.

Rapid, systematic updating of movement by accumulated decision evidence.

Acting in the natural world requires not only deciding among multiple options but also converting decisions into motor commands. How the dynamics of decision formation influence the fine kinematics of response movement remains, however, poorly understood. Here we investigate how the accumulation of decision evidence shapes the response orienting trajectories in a task where freely-moving rats combine prior expectations and auditory information to select between two possible options.

Coupled environmental and demographic fluctuations shape the evolution of cooperative antimicrobial resistance.

There is a pressing need to better understand how microbial populations respond to antimicrobial drugs, and to find mechanisms to possibly eradicate antimicrobial-resistant cells. The inactivation of antimicrobials by resistant microbes can often be viewed as a cooperative behaviour leading to the coexistence of resistant and sensitive cells in large populations and static environments. This picture is, however, greatly altered by the fluctuations arising in volatile environments, in which microbial communities commonly evolve.

Exact face-landing probabilities for bouncing objects: Edge probability in the coin toss and the three-sided die problem.

Have you ever taken a disputed decision by tossing a coin and checking its landing side? This ancestral "heads or tails" practice is still widely used when facing undecided alternatives since it relies on the intuitive fairness of equiprobability. However, it critically disregards an interesting third outcome: the possibility of the coin coming at rest on its edge. Provided this evident yet elusive possibility, previous works have already focused on capturing all three landing probabilities of thick coins, but have only succeeded computationally.

Proactive and reactive accumulation-to-bound processes compete during perceptual decisions.

Standard models of perceptual decision-making postulate that a response is triggered in reaction to stimulus presentation when the accumulated stimulus evidence reaches a decision threshold. This framework excludes however the possibility that informed responses are generated proactively at a time independent of stimulus. Here, we find that, in a free reaction time auditory task in rats, reactive and proactive responses coexist, suggesting that choice selection and motor initiation, commonly viewed as serial processes, are decoupled in general.

Dominance of Metric Correlations in Two-Dimensional Neuronal Cultures Described through a Random Field Ising Model.

We introduce a novel random field Ising model, grounded on experimental observations, to assess the importance of metric correlations in cortical circuits in vitro. Metric correlations arise from both the finite axonal length and the heterogeneity in the spatial arrangement of neurons. The experiments consider the response of neuronal cultures to an external electric stimulation for a gradually weaker connectivity strength between neurons, and in cultures with different spatial configurations.