Publications by authors named "Lluis Camprubi Ferrer"
Dopaminergic neurons lacking Caspase-3 avoid apoptosis but undergo necrosis after MPTP treatment inducing a Galectin-3-dependent selective microglial phagocytic response.
Cell Death Dis
August 2024
Article Synopsis
- Parkinson's Disease (PD) is linked to the loss of dopamine-producing neurons, with apoptosis being a significant factor in its progression.
- A study created a genetic model (TH-C3KO) to investigate the effects of removing the apoptosis-related gene Casp3 in dopaminergic neurons, finding that this deletion did not provide long-term protection against neuron loss and actually switched the cell death mechanism to necrosis.
- The research also revealed an intensified microglial response in TH-C3KO mice, indicating that targeting galectin-3 and microglial behavior could be more effective strategies for developing PD therapies instead of focusing solely on apoptosis inhibition.
Our diets greatly influence our health. Multiple lines of research highlight the beneficial properties of eating berries and fruits. In this study, a berry mixture of Nordic berries previously identified as having the potential to improve memory was supplemented to young C57Bl/6J male mice to investigate effects on cognition function, metabolic health, markers of neuroinflammation, and gut microbiota composition.
View Article and Find Full Text PDFMicroglia have an innate immunity memory (IIM) with divergent functions in different animal models of neurodegenerative diseases, including Alzheimer's disease (AD). AD is characterized by chronic neuroinflammation, neurodegeneration, tau tangles and β-amyloid (Aβ) deposition. Systemic inflammation has been implicated in contributing to the progression of AD.
View Article and Find Full Text PDFParkinson's Disease (PD) is a neurodegenerative and progressive disorder characterised by intracytoplasmic inclusions called Lewy bodies (LB) and degeneration of dopaminergic neurons in the substantia nigra (SN). Aggregated α-synuclein (αSYN) is known to be the main component of the LB. It has also been reported to interact with several proteins and organelles.
View Article and Find Full Text PDFArticle Synopsis
- ApoE is crucial for lipid and cholesterol transport in the central nervous system (CNS), with three main variations (apoE2, apoE3, apoE4), where APOE4 significantly increases the risk of late-onset Alzheimer's disease (AD).
- The review explores the evolution of apoE and how its genetic variations affect its function and structure, influencing key aspects of AD pathology like neuroinflammation, amyloid-β accumulation, and tau-related issues.
- Additionally, the text examines how APOE genotype interacts with factors like age, sex, diet, and therapies in AD and its role in other neurodegenerative diseases marked by inflammation, broadening the understanding of APOE's impact on CNS health.
Galectin-3 (Gal-3) is a beta-galactosidase binding protein involved in microglial activation in the central nervous system (CNS). We previously demonstrated the crucial deleterious role of Gal-3 in microglial activation in Alzheimer's disease (AD). Under AD conditions, Gal-3 is primarily expressed by microglial cells clustered around Aβ plaques in both human and mouse brain, and knocking out Gal-3 reduces AD pathology in AD-model mice.
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