Publications by authors named "Lloyd Ruiz"
Article Synopsis
- - The study focuses on skeletal muscle's vital role in movement and metabolism, emphasizing the challenge of mapping gene expression in muscle tissue due to current technological limitations.
- - Researchers utilized a new technique called Seq-Scope, which allows for high-resolution observation of gene expression in mouse soleus muscle, analyzing differences between healthy and denervated conditions that simulate aging.
- - Findings reveal detailed insights into muscle composition and gene expression related to muscle injury, contributing greatly to the understanding of muscle function decline with age and paving the way for potential new treatments to enhance muscle health.
Understanding neuromuscular junction (NMJ) repair mechanisms is essential for addressing degenerative neuromuscular conditions. Here, we focus on the role of muscle-resident Schwann cells in NMJ reinnervation. In young mice, a model of progressive NMJ degeneration, we identified a clear NMJ 'regenerative window' that allowed us to define regulators of reinnervation and crossing mice with -tg mice permitted visualization and analysis of Schwann cells.
View Article and Find Full Text PDFMaintenance of subsynaptic myonuclei number is not driven by neural input.
Front Physiol
September 2023
The development and maintenance of neuromuscular junctions (NMJ) are supported by a specialized population of myonuclei that are referred to as the subsynaptic myonuclei (SSM). The relationship between the number of SSM and the integrity of the NMJ as well as the impact of a loss of innervation on SSM remain unclear. This study aimed to clarify these associations by simultaneously analyzing SSM counts and NMJ innervation status in three distinct mouse models of acute and chronic NMJ disruption.
View Article and Find Full Text PDFContractions of skeletal muscles provide the stability and power for all body movements. Consequently, any impairment in skeletal muscle function results in some degree of instability or immobility. Factors that influence skeletal muscle structure and function are therefore of great interest scientifically and clinically.
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