Publications by authors named "Lloyd L Liang"
Background: Integrative multiomics can elucidate pulmonary arterial hypertension (PAH) pathobiology, but procuring human PAH lung samples is rare.
Methods: We leveraged transcriptomic profiling and deep phenotyping of the largest multicenter PAH lung biobank to date (96 disease and 52 control) by integration with clinicopathologic data, genome-wide association studies, Bayesian regulatory networks, single-cell transcriptomics, and pharmacotranscriptomics.
Results: We identified 2 potentially protective gene network modules associated with vascular cells, and we validated , coding for asporin, as a key hub gene that is upregulated as a compensatory response to counteract PAH.
Article Synopsis
- A study examined the connection between erythropoietic abnormalities and pulmonary arterial hypertension (PAH), finding that these issues are common in PAH patients and linked to more severe disease.
- The research involved 67 PAH patients and analyzed various blood parameters, discovering that immature reticulocyte fraction (IRF) positively correlates with worse hemodynamic measures, like mean pulmonary artery pressure, while negatively impacting cardiac output.
- IRF emerges as a significant biomarker for assessing the severity of PAH, tied to both erythropoiesis and iron metabolism challenges in patients.
Introduction: Evidence suggests that abnormalities occur in the lung microvasculature in idiopathic pulmonary fibrosis (IPF). We hypothesised that dynamic contrast-enhanced (DCE)-magnetic resonance imaging (MRI) could detect alterations in permeability, perfusion and extracellular extravascular volume in IPF, thus providing regional functional information not otherwise available.
Methods: Healthy controls and IPF subjects underwent DCE-MRI of the thorax using a dynamic volumetric radial sampling sequence and administration of gadoterate meglumine at a dose of 0.
Early, accurate diagnosis of interstitial lung disease (ILD) informs prognosis and therapy, especially in idiopathic pulmonary fibrosis (IPF). Current diagnostic methods are imperfect. High-resolution computed tomography has limited resolution, and surgical lung biopsy (SLB) carries risks of morbidity and mortality.
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- - Sweet's Syndrome (SS) is an inflammatory skin condition characterized by the presence of neutrophils and is a type of neutrophilic dermatosis.
- - There are fewer than 50 documented cases of respiratory complications related to SS, but this article discusses a unique case involving lung transplantation (LT).
- - The study highlights the clinical journey of the first patient who underwent LT for pulmonary SS and suggests that the lung disease may recur in the transplanted organ.
Purpose: Computed tomography (CT) imaging is the standard to assess interstitial lung disease. Magnetic resonance (MR) is potentially advantageous due to superior tissue characterization and better assessment of blood flow dynamics. This study aimed to evaluate idiopathic pulmonary fibrosis (IPF) using prototype 4D Stack of Stars GRE (StarVIBE) MR and compare it to CT.
View Article and Find Full Text PDFBackground: Some interstitial lung disease (ILD) patients develop a progressive fibrosing-ILD phenotype (PF-ILD), with similar persistent lung function decline suggesting common molecular pathways involved. Nintedanib, a tyrosine kinase inhibitor targeting the PDGF, FGF, VEGF and M-CSF pathways, has shown comparable efficacy in idiopathic pulmonary fibrosis (IPF) and systemic sclerosis-associated ILD (SSc-ILD). We hypothesize that Nintedanib targeted molecular pathways will be augmented to a similar degree across PF-ILD regardless of aetiology.
View Article and Find Full Text PDFVascular leak is increased diffusely in the lungs in pulmonary fibrosis and is not limited to radiographic areas of disease involvement.
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