Polyoxygenated Cyclohexenes from with Multi-Enzyme Targeting Properties Relevant in Type 2 Diabetes and Obesity.

Shikimic acid-derived polyoxygenated cyclohexene natural products commonly occurring in several species of the represent natural products with promising biological activities. While a number of derivatives have been reported from (), further studies are needed to discover additional bioactive congeners, particularly derivatives with multi-protein target inhibitory properties implicated in diseases such as diabetes and obesity. In this paper, isolation and identification of a new highly oxygenated cyclohexene, uvagrandol (), along with the known compound (-)-zeylenone () from the DCM sub-extract of following and assessment of their enzyme inhibitory properties against α-glucosidase, dipeptidyl peptidase IV, porcine lipase, and human recombinant monoacylglycerol lipase are reported.