Publications by authors named "Llenalia Garcia"
Modeling study of the effect of placebo and medical therapy on storage and voiding symptoms, nocturia, and quality of life in men with prostate enlargement at risk for progression.
Prostate Cancer Prostatic Dis
September 2024
Article Synopsis
- This study looked at how different treatments for prostate problems affect symptoms like needing to go to the bathroom often, trouble starting to pee, and nighttime trips to the bathroom.
- Researchers used data from a specific study to see which treatments helped the most and what factors (like age and previous treatments) influenced these results.
- They found that combination therapy was better than single treatments for most patients and created an interactive tool online to show these results clearly.
Article Synopsis
- The study evaluates the effectiveness of the Hidradenitis Suppurativa Investigator Global Assessment (HS-IGA) score as a measurement tool in clinical trials for hidradenitis suppurativa (HS).
- Data from a phase 2 trial with adults suffering from moderate-to-severe HS was analyzed, focusing on the HS-IGA score's validity and reliability over a 12-week period.
- Results revealed that the HS-IGA score correlates strongly with other measures of HS severity, showing good reliability and being a useful potential endpoint in HS clinical trials, despite limited predictive validity with patient-reported outcomes.
Multiple sclerosis (MS) is an inflammatory autoimmune disease associated with genetic and environmental factors. Cigarette smoking is harmful to health and may be one of the risk factors for MS. However, there have been no systematic investigations under controlled experimental conditions linking cigarette smoke (CS) and MS.
View Article and Find Full Text PDFβ-hydroxy β-methylbutyrate (HMB), a metabolite of the essential amino acid leucine, has been shown to preserve muscle mass and strength during aging. The signaling mechanism by which HMB elicits its favorable effects on protein metabolism in skeletal muscle is also preserved in the brain. However, there are only a few studies, all at relatively high doses, addressing the effect of HMB supplementation on cognition.
View Article and Find Full Text PDFArticle Synopsis
- This analysis evaluated the Psoriasis Symptoms and Impacts Measure (P-SIM), a new tool that helps capture how psoriasis affects patients' lives.
- Data from a clinical trial comparing bimekizumab and secukinumab were used to test the P-SIM for reliability and validity.
- Results indicated that P-SIM items had strong reliability and they effectively distinguished between different levels of psoriasis severity while showing sensitivity to changes in patients' conditions over time.
Article Synopsis
- Plaque psoriasis negatively affects patients' quality of life, and the Psoriasis Symptoms and Impacts Measure (P-SIM) was developed to evaluate their experiences with the condition.
- A study involving 1,002 patients analyzed data from two clinical trials to assess the reliability and validity of P-SIM, including test-retest reliability, convergent validity with other outcome measures, and sensitivity to change over 16 weeks.
- Results showed that P-SIM demonstrated excellent reproducibility, strong correlations with other patient-reported outcomes, and effectively distinguished between patient subgroups, confirming its reliability and sensitivity in measuring the impact of psoriasis.
Background: Inflammatory bowel disease (IBD) is the collective term for chronic immune-mediated diseases of unknown, multifactorial etiology, arising from the interplay between genetic and environmental factors and including two main disease manifestations: ulcerative colitis (UC) and Crohn's disease. In the last few decades, naturally occurring alkaloids have gained interest because of their substantial anti-inflammatory effects in several animal models of disease. Studies on mouse models of IBD have demonstrated the anti-inflammatory action of the main tobacco alkaloid, nicotine.
View Article and Find Full Text PDFInterleukin (IL) 1-ra is a potent endogenous competitive inhibitor of IL-α and β and has an anti-inflammatory role. Study objectives were: 1) to assess the associations of IL-1RN genetic single nucleotide polymorphism (SNP) (rs419598) with generalized chronic periodontitis (GCP), generalized aggressive periodontitis (GAgP), and absence of periodontitis and 2) to assess its association with the load of five periodontopathogenic bacteria and periodontal clinical variables. A cross-sectional analytic study was conducted in 123 patients with GCP, 60 patients with GAgP, and 20 controls.
View Article and Find Full Text PDF