Research progress in cardiotoxicity of organophosphate esters.

Organophosphate esters (OPEs) have been extensively utilized worldwide as a substitution for brominated flame retardants. With an increased awareness of the need for environmental protection, the potential health risks and ecological hazards of OPEs have attracted widespread attention. As the dynamic organ of the circulatory system, the heart plays a significant role in maintaining normal life activities.

The progress of research into pseudophosphatases.

Pseudophosphatases are a class of phosphatases that mutate at the catalytically active site. They play important parts in many life processes and disorders, e.g.

Identification of pimavanserin tartrate as a potent Ca-calcineurin-NFAT pathway inhibitor for glioblastoma therapy.

Glioblastoma multiforme (GBM) is the most common and malignant type of primary brain tumor, and 95% of patients die within 2 years after diagnosis. In this study, aiming to overcome chemoresistance to the first-line drug temozolomide (TMZ), we carried out research to discover a novel alternative drug targeting the oncogenic NFAT signaling pathway for GBM therapy. To accelerate the drug's clinical application, we took advantage of a drug repurposing strategy to identify novel NFAT signaling pathway inhibitors.

CondenseNet with exclusive lasso regularization.

Group convolution has been widely used in deep learning community to achieve computation efficiency. In this paper, we develop CondenseNet-elasso to eliminate feature correlation among different convolution groups and alleviate neural network's overfitting problem. It applies exclusive lasso regularization on CondenseNet.

Heart rate variability monitoring for emotion and disorders of emotion.

Background: Emotion is composed of cognitive processing, physiological response and behavioral reaction. Heart rate variability (HRV) refers to the fluctuations between consecutive heartbeat cycles, and is considered as a non-invasive method for evaluating cardiac autonomic function. HRV analysis plays an important role in emotional study and detection.

The online monitoring and assessment of thallium stress using oxygen consumption rate and carbon dioxide excretion rate of zebrafish (Danio rerio).

An online monitoring and assessment system of metabolism to measure oxygen consumption rate (OC) and carbon dioxide (CO) excretion rate (CR) of zebrafish (Danio rerio) was used to illustrate changes in stressful states in 15 days' (360 h) 0.1 μg/L Tl exposure. Tl had a significant inhibition on zebrafish OC and CR (p < 0.

Toxic responses of zebrafish (Danio rerio) to thallium and deltamethrin characterized in the electrocardiogram.

The electrocardiogram (ECG) has been widely used to objectively address the physical condition as an index of stress. Though a numerous accounts of investigations on aquatic organisms' ECGs have been made, differentiation of ECG parameters in responding to specific toxic chemicals has not been extensively studied. In this research, it is hypothesized that zebrafish (Danio rerio) ECG parameters would differently respond to different types of pollutants, a heavy metal, thallium (Tl, 0.

Increased pulse wave transit time after percutaneous coronary intervention procedure in CAD patients.

Pulse wave transit time (PWTT) has been widely used as an index in assessing arterial stiffness. Percutaneous coronary intervention (PCI) is usually applied to the treatment of coronary artery disease (CAD). Research on the changes in PWTT caused by PCI is helpful for understanding the impact of the PCI procedure.

Area asymmetry of heart rate variability signal.

Background: Heart rate fluctuates beat-by-beat asymmetrically which is known as heart rate asymmetry (HRA). It is challenging to assess HRA robustly based on short-term heartbeat interval series.

Method: An area index (AI) was developed that combines the distance and phase angle information of points in the Poincaré plot.

Cadmium stress assessment based on the electrocardiogram characteristics of zebra fish (Danio rerio): QRS complex could play an important role.

The electrocardiogram (ECG) of zebra fish (Danio rerio) expresses cardiac features that are similar to humans. Here we use sharp microelectrode measurements to obtain ECG characteristics in adult zebra fish and analyze the effects of cadmium chloride (CdCl) on the heart. We observe the overall changes of ECG parameters in different treatments (0.

Comparison of heart rate variability between resting state and external-cuff-inflation-and-deflation state: a pilot study.

Heart rate variability (HRV) has been widely used in clinical research to provide an insight into the autonomic control of the cardiovascular system. Measurement of HRV is generally performed under a relaxed resting state. The effects of other conditions on HRV measurement, such as running, mountaineering, head-up tilt, etc, have also been investigated.

Analysis of short-term heart rate and diastolic period variability using a refined fuzzy entropy method.

Background: Heart rate variability (HRV) has been widely used in the non-invasive evaluation of cardiovascular function. Recent studies have also attached great importance to the cardiac diastolic period variability (DPV) examination. Short-term variability measurement (e.