Publications by authors named "Lizet Sanchez-Valdes"

Background: COVID-19 vaccines have proven safe and efficacious in reducing severe illness and death. Cuban protein subunit vaccine Abdala has shown safety, tolerability and efficacy (92·3% [95% CI: 85·7‒95·8]) against SARS-CoV-2 in clinical trials. This study aimed to estimate Abdala's real-world vaccine effectiveness (VE).

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Background: Nimotuzumab is a humanized monoclonal antibody that targets the epidermal growth factor receptor. It was approved in Cuba for the indication of inoperable malignant tumors of the esophagus of epithelial origin. The purpose of this study was to evaluate the safety, overall and progression-free survival, clinical response, and quality of life, in adult patients with inoperable esophageal tumors of epithelial origin treated with nimotuzumab in a practical context.

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Cuba's National Health System has managed to guarantee an effective and equitable response to COVID-19. Universal and free health coverage, based on primary care, follows the principle of equity and the greatest resources are allocated to areas of the lowest socioeconomic stratum (where higher risk is concentrated), followed by those of medium and high strata, in that order. This allowed for similar mortality rates in the three strata, and Cuban national mortality rate was one of the lowest in the Region of the Americas.

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Cuba's National Health System has managed to guarantee an effective and equitable response to COVID-19. Universal and free health coverage, based on primary care, follows the principle of equity, and the greatest resources are allocated to areas of the lowest socioeconomic stratum (which concentrates the higher health risks), followed by those of medium and high strata, in that order. This allowed for similar mortality rates in the three strata, and Cuban national mortality rate was one of the lowest in the Region of the Americas.

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Objectives: To describe the variation and the trend of new tuberculosis case reports in Havana from 1995 to 2010, as well as their projection and occurrence for 2011-2013.

Methods: A time series study was conducted, and the annual total and mean variation percentages of rates by clinical and bacteriological categories, age, municipal distribution and TB/HIV co-infection were analyzed. Estimation of projections by using two-parameter exponential smoothing techniques was made.

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Introduction: dengue is a viral disease with endemic behavior. At the beginning of the illness it is not possible to know which patients will have an unfavorable evolution and develop a severe form of dengue. However, some warning symptoms and signs may be present.

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Introduction: Aedes aegypti is a common vector in Cuba, which damages human health. Santiago de Cuba is one of the provinces with high number of mosquito foci in a sustained way. Therefore, it is very important, from the social viewpoint, to carry out educational interventions with anti-vector campaign workers in Mella municipality in this province.

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Introduction: the studies on population's knowledge and perceptions of infectious diseases contribute to develop more effective communication processes.

Objective: to evaluate the knowledge and the perception of the residents in Habana Vieja municipality about tuberculosis, and to identify the ways for obtaining information about aspects of this disease.

Methods: a cross-sectional study was carried out.

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Objective: identify Cuban municipalities with high, medium, and low incidence of tuberculosis (TB), compare incidence rates for the periods 1999-2002 and 2003-2006, and analyze distribution of the disease by population density and economic activity.

Methods: TB incidence was calculated by municipality, confidence interval (95%), and the percentage of variation for the defined strata according to population density and the predominant economic activity. The municipalities were divided into three categories based on incidence (> 10 per 100 000; > 5 per 100 000 to < 10 per 100 000, and < 5 per 100 000), and maps were plotted.

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Introduction: the population's knowledge is important to develop participatory processes that support the reduction of Aedes aegypti.

Objectives: to identify sociodemographic factors, knowledge, perceptions and practice in the population of three people's councils in Lisa municipality about Aedes aegypti control and dengue prevention; to determine the association of these sociodemographic factors with the adequate level of knowledge about dengue, and relate the implementation of suitable practice to risk knowledge and perceptions.

Methods: cross-sectional study was conducted in which surveys and an observational guide were applied to a randomized sample of individuals living in the selected areas.

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Introduction: the continuous use of the organophosphate temephos for Aedes (Stegomyia) aegypti (Linnaeus, 1762) has prompted the emergence of resistance to this product in several countries. Pyriproxyfen is an analogue of the juvenile hormone recommended by the World Health Organization as one of the alternative regulators of the dengue vector in drinking waters.

Objectives: to evaluate the efficacy of pyriproxyfen in those strains with various degrees of temephos resistance, in order to be used as a possible regulator of Ae.

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Objective: to ascertain the level of knowledge, the perceptions and practice of dermatologists in the City of Havana with respect to Giardia lamblia infection.

Methods: with prior informed consent given by the dermatologists from the City of Havana, 50 dermatologists- a number very close to the universe of these experts in the province- were administered a survey of their knowledge, perceptions and practice about this parasitosis. The survey was prepared in 4 phases; that is, interviews to physicians on diagnosis, treatment and control of giardiasis; drafting of a preliminary questionnaire based on the interview results; submission of this instruments to the experts, and finally its validation through its application to a small group of physicians.

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Introduction: Aedes aegypti is the main dengue and hemorrhagic dengue vector and its widespread behavior responds to a number of factors, among them, the climatic ones.

Objectives: to determine the behavior of Aedes aegypti mosquitoes depending on season and weather conditions and how it relates with climatic factors such as temperature and rain.

Methods: a descriptive seasonal and weather study was made on the basis of data given by the provincial weather center and the surveillance anti-vector fight unit located in Sancti Spiritus province, which covered the 1999-2007 period.

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An AIDS epidemic is an important challenge to human survival. Although the prevalence in Cuba is below 0.1% in adult people, this disease is a priority problem.

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Three studies were conducted in Cienfuegos province to prove that intestinal amebiasis in Cuba could be an overestimated health problem. The first two studies showed two components of this overestimation: microscopical overdiagnosis and lack of knowledge about Entamoeba dispar, a non-pathogenic species, in most cases in which microscopical examination was correct. This paper reported the third study that showed the third component: the wrong belief that Entamoeba histolytica is resistant to metronidazole.

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In a study conducted in the province of Cienfuegos, it was proved by using immunological and biomolecular tools that intestina amebiasis in that province was an overdimensioned health problem. A survey on knowledge, perceptions and practices applied to those physicians related to the diagnosis, treatment and control of this parasitosis showed that the overdimensioning may be associated with an inadequate perception of the problem and with a marked lack of knowledge about important aspects of this entity. To contribute to the solution of the ovedimensioning and of its consequences, a set of actions were taken in that province.

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