Background: The CATSPER1 gene encodes a CATSPER channel protein that selectively permeates Ca ions, and CATSPER expression in sperm is essential for flagellum hyperactivation and, thus, male fertility. Little is known regarding the transcriptional regulation of CATSPER1, but previous studies have performed in silico analyses of transcription factor binding sites, including three CRE sites designated 0-2, in which CRE0 is located near the transcription start site.
Objetives: We investigate if overexpression of CREB-A and CREMτ transcription factors might regulate CATSPER1 expression.