Publications by authors named "Lizandra Vitoria de Souza Santos"
Molecular docking and analysis of the pharmacokinetics, toxicological profile and differential gene expression of bioactive compounds from .
Toxicol Rep
December 2024
Article Synopsis
- The study focuses on a genus of plants known for their therapeutic properties, particularly for treating conditions like tuberculosis and urinary infections, with an emphasis on a species endemic to Brazil.
- It identifies and analyzes the main compounds in its aqueous extract, finding Arbutin, Caffeic acid 4-O-glucoside, and Dihydroformononetin to be the most abundant; the gastrointestinal absorption and ability to cross the blood-brain barrier of these compounds were evaluated.
- The research indicates that Arbutin and Dihydroformononetin may lead to drug synthesis and shows potential for phytotherapeutic use, although some mutagenicity predictions require cautious interpretation.
Phenolic phytometabolites are promising bioactive compounds for management of genomic instability related diseases. Formononetin (FMN) and arbutin (ARB) are found in several plant sources. Our goal was to investigate the safety and efficacy of FMN and ARB using both standardized and alternative toxicogenetic methods.
View Article and Find Full Text PDFAntiplasmodial, Trypanocidal, and Genotoxicity Assessment of New Hybrid α,α-Difluorophenylacetamide-statin Derivatives.
Pharmaceuticals (Basel)
May 2023
Background: Statins present a plethora of pleiotropic effects including anti-inflammatory and antimicrobial responses. A,α-difluorophenylacetamides, analogs of diclofenac, are potent pre-clinical anti-inflammatory non-steroidal drugs. Molecular hybridization based on the combination of pharmacophoric moieties has emerged as a strategy for the development of new candidates aiming to obtain multitarget ligands.
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