Genomic markers for ovarian cancer at chromosomes 1, 8 and 17 revealed by array CGH analysis.

Aims And Background: The literature data show that the most frequently affected chromosomes in ovarian carcinogenesis are 1, 8 and 17. In the present study we aimed to define more precisely at a high resolution the genomic imbalances of these chromosomes in ovarian cancer and to determine genomic markers separating tumors of different histological types and stages.

Methods: Array comparative genomic hybridization (CGH) with a resolution of approximately 0.