Niosomal entrapment improved the bactericidal properties of azithromycin against methicillin-resistant .

This study seeks to optimize niosomal formulations of azithromycin (AZ) and evaluate their activities against methicillin-resistant (MRSA). The thin-film hydration was used to prepare niosomes containing various molar ratios of span 60, cholesterol, dicetylphosphate and AZ. Formulation 5, with 5:1:1:1 molar ratio, was optimized based on entrapment efficiency.

Brinzolamide-loaded soft contact lens for ophthalmic delivery.

In this study, brinzolamide (BRZ) was loaded in balafilcon A silicone hydrogel soft contact lens to enhance delivery in glaucoma therapy. BRZ-loaded soft contact lens was prepared by the soaking method with optimization of pH, temperature and concentration of drug loading solution. At pH 7.