Publications by authors named "Liz Arram"
Article Synopsis
- The study aimed to determine the effectiveness and safety of starting direct oral anticoagulants (DOACs) early versus delayed in patients with acute ischaemic stroke and atrial fibrillation.
- Conducted as a multicenter, randomized controlled trial across 100 UK hospitals, 3,648 patients were initially assigned to either early initiation (within 4 days) or delayed initiation (7-14 days) of anticoagulation.
- The primary outcome measured was the incidence of complications like recurrent stroke or bleeding within 90 days, with results being analyzed by an independent committee to ensure objectivity.
Article Synopsis
- Atrial fibrillation is linked to a significant percentage of ischemic strokes, prompting the need for effective early anticoagulation to reduce the risk of stroke recurrence.
- The OPTIMAS study tests if starting direct oral anticoagulants within four days post-stroke is more effective than delaying treatment for 7-14 days.
- The research will assess outcomes like recurrent stroke and major bleeding, involving nearly 3,500 participants across UK centers to evaluate the safety and effectiveness of early anticoagulation.
