Plast Reconstr Surg Glob Open
March 2024
Background: Mallet finger deformity is a prevalent disability that causes discomfort and inconvenience to the patients. Despite the existence of various surgical approaches, surgical management remains a controversial subject.
Methods: We retrospectively analyzed the clinical data of 26 patients with isolated tendinous mallet fingers who were admitted between January 2021 and June 2022.
Background: Pulmonary fibrosis (PF) is a progressive lung disorder with a high mortality rate; its therapy remains limited due to the inefficiency of drug delivery. In this study, the system of drug delivery of nintedanib (Nin) by exosomes derived from adipose-derived stem cells (ADSCs-Exo, Exo) was developed to effectively deliver Nin to lung lesion tissue to ensure enhanced anti-fibrosis therapy.
Methods: The bleomycin (BLM)-induced PF model was constructed in vivo and in vitro.
In this study, co-culture of microalgae and activated sludge in photobioreactors (PBRs) was investigated at different inoculation ratios (0:1, 0.3:1, 0.7:1, and 1.
View Article and Find Full Text PDFIt is widely accepted that genetic polymorphisms impact atorvastatin (ATV) metabolism, clinical efficacy, and adverse events. The objectives of this study were to identify novel genetic variants influencing ATV metabolism and outcomes in Chinese patients with coronary artery disease (CAD). A total of 1079 CAD patients were enrolled and followed for 5 years.
View Article and Find Full Text PDFIn this work, the effect of a modified metal organic framework material on the fire resistance and mechanical properties of epoxy resin (EP) has been explored. The cobalt based metal organic framework (ZIF-67) was synthesized from an organic ligand with a Schiff base structure. Then DOPO@ZIF-67 was synthesized by modifying ZIF-67 with 9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide (DOPO), and its effect on EP modification was explored.
View Article and Find Full Text PDFThe selection of optimum statin intensity is inconclusive, and the association of plasma exposure of statins and metabolites with major adverse cardiovascular events (MACEs) is unclear. This study sought to compare the effect of low (quartile 1), intermediate (quartiles 2 and 3), and high (quartile 4) plasma exposure of statins and metabolites on MACE, re-ischemia events and death in patients with coronary artery disease (CAD) at 5 years. A total of 1,644 patients in atorvastatin (AT) cohort and 804 patients in rosuvastatin (RST) cohort were included, and their plasma concentration of statins and metabolites was categorized as low-, mid-, or high-group.
View Article and Find Full Text PDFHuan Jing Ke Xue
February 2018
The relationship between microbial populations and sludge filtration performance was studied when active sludge was used to treat the leachate from municipal solid waste incineration plants. Two SBRs (SBR1 and SBR2) were operated at the same conditions, except that SBR1 was exposed to the sunlight and SBR2 was in the dark. To identify the difference in microbial populations in two reactors, high-throughput sequencing method was used.
View Article and Find Full Text PDFThe role of statins in reducing the incidence of contrast-induced acute kidney injury (CI-AKI) remains controversial. We sought to evaluate the association between CI-AKI and high plasma exposure of statins in coronary artery disease (CAD) patients undergoing coronary angiography (CAG). This association was first evaluated in 1,219 patients with CAD receiving atorvastatin (AT) therapy and validated in 635 patients receiving rosuvastatin (RST) therapy.
View Article and Find Full Text PDFIntroduction And Objective: The relationship between either paraoxonase 1 (PON1) gene promoter DNA methylation or genetic variations and bleeding or major adverse cardiac events after dual antiplatelet therapy has been incompletely characterized. We aimed to systematically investigate the role of genetic variations and DNA methylation of the PON1 CpG island promoter on the clinical outcomes of dual antiplatelet therapy for patients with coronary artery disease (CAD) who underwent percutaneous coronary intervention (PCI).
Methods: This study included 653 patients with CAD undergoing PCI and receiving dual antiplatelet therapy.
Purpose: This nested case-control study aimed to evaluate the association of candidate genetic variants with statin-induced myotoxicity in Chinese patients with coronary artery disease (CAD).
Methods: One hundred forty-eight Chinese patients experiencing statin-induced myotoxicity were included in our study, and 255 patients without muscular side effects served as controls. Five SNPs in CYP3A5, SLCO1B1, and APOE were genotyped.
The purpose of this study is to systematically investigate the characteristics of absorption and metabolism of oxymatrine (OMT) using rat intestinal perfusion model. Ultra performance liquid chromatography (UPLC) and high performance liquid chromatography-electrospray ionization-quadrupole-time of flight mass spectrometry (HPLC-ESI(+)-Q-TOF-MS) were used to test absorption of OMT in intestine at 100, 200 and 400 µmol · L(-1). The absorption rate and permeability of OMT is not dependent on concentration, but through passive absorption in intestine (P > 0.
View Article and Find Full Text PDFApurinic/apyrimidinic endonuclease 1 (APE1) is a key enzyme in base excision repair (BER) pathway for the removal of many oxidized and alkylated bases. Single-nucleotide polymorphisms of the APE1gene have been demonstrated to be involved in carcinogenesis. However, the association between APE1 Asp148Glu polymorphism and lung cancer risk remains inconclusive.
View Article and Find Full Text PDFBackground: To predict the recurrence of atrial fibrillation is important for selecting patients who will be undergoing catheter ablation, several studies respectively evaluated the risk factor of the recurrence of atrial fibrillation post-ablation.
Objective: To investigate the factors predicting the recurrence of atrial fibrillation (AF) after catheter ablation.
Methods: 186 patients (55.