Publications by authors named "Liyuan Zhou"

Background: The current knowledge about the efficacy and safety of dietary polyphenol administration in patients with polycystic ovarian syndrome (PCOS) is divergent.

Objective: To evaluate the pooled efficacy and safety of dietary polyphenol administration in the treatment of patients with PCOS.

Methods: The pubmed, Embase, Scopus, Cochrane Library, and Web of Science databases were searched for randomized controlled trials (RCTs) of dietary polyphenol administration for the treatment of PCOS.

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Biomass-burning organic aerosol(s) (BBOA) are rich in brown carbon, which significantly absorbs solar irradiation and potentially accelerates global warming. Despite its importance, the multiphase photochemistry of BBOA after light absorption remains poorly understood due to challenges in determining the oxidant concentrations and the reaction kinetics within aerosol particles. In this study, we explored the photochemical reactivity of BBOA particles in multiphase S(IV) oxidation to sulfate.

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Poor intrauterine environments increase the prevalence for chronic metabolic diseases in offspring, whereas maternal exercise is an effective measure to break this vicious intergenerational cycle. Placenta is increasingly being studied to explore its role in maternal-fetal metabolic cross-talk. The association between placental miRNA and offspring development trajectories has been established, yet the specific role and mechanism thereof in maternal exercise-induced metabolic protection remain elusive.

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Metabolic diseases, including obesity, dyslipidemia, and type 2 diabetes, have become severe challenges worldwide. The Developmental Origins of Health and Disease (DOHaD) hypothesis suggests that an adverse intrauterine environment can increase the risk of metabolic disorders in offspring. Studies have demonstrated that maternal exercise is an effective intervention for improving the offspring metabolic health.

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  • Microcapsules are a promising delivery system, with their mechanical properties influencing their suitable applications, such as biomedical uses where lower strength is preferred for better biocompatibility.
  • The paper outlines four methods for characterizing the mechanical properties of microcapsules: nanoindentation, parallel plate compression, microcapillary technology, and flow deformation.
  • It discusses how to regulate these properties through size and shape changes, incorporating sacrificial bonds, and creating hybrid shells, while also exploring future applications in fields like food, textiles, and pharmaceuticals.
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Traditional pressure-sensitive microcapsules used in textiles face challenges of insufficient environmental friendliness in the production process and uncontrollable fragrance release. To address this issue, this study utilized quaternary ammonium chitosan and silica as wall materials to develop a magnetic aromatic microcapsule. The microstructure of the microcapsules was controlled by magnetic field induction, and its evolution pattern was investigated.

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  • * While there were some changes in liver gene expression related to mitochondrial function and inflammation, the typical circadian rhythms and gut microbiota appeared relatively unaffected.
  • * Remarkably, these changes may offer first-generation offspring increased protection against obesity when they are later exposed to a high-fat diet.
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  • Familial partial lipodystrophy 3 (FPLD3) is a rare genetic disorder caused by mutations affecting the PPARγ protein, leading to loss of subcutaneous fat and metabolic issues.
  • A study on a 17-year-old Chinese girl with FPLD3 identified a new mutation that truncates the PPARγ protein and found that various circRNAs, miRNAs, and mRNAs are significantly altered in mutation carriers compared to healthy controls.
  • The research highlights the role of circ_0001597 and miR-671-5p in regulating genes linked to glucose and lipid metabolism, suggesting potential biomarkers and new treatment options for FPLD3.
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Developing a general method that leads to the formation of different classes of chiral bioactive compounds and their stereoisomers is an attractive but challenging research topic in organic synthesis. Furthermore, despite the great value of asymmetric transfer hydrogenation (ATH) in both organic synthesis and the pharmaceutical industry, the monohydrogenation of unsymmetrical 1,2-diketones remains underdeveloped. Here, we report the aryloxy group-assisted highly regio-, diastereo-, and enantioselective ATH of racemic 1,2-diketones.

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  • - Most cases of Hereditary Severe Insulin Resistance Syndrome (H-SIRS) are caused by mutations in the insulin receptor gene, leading to problems like high insulin levels, diabetes, and associated symptoms.
  • - In a recent report, two female children with H-SIRS showed multiple symptoms, including hyperinsulinemia, fasting hypoglycemia, and hyperandrogenism, along with one patient experiencing mental retardation.
  • - Genetic testing revealed two specific mutations in the insulin receptor gene that disrupt normal insulin signaling, contributing to the patients' insulin resistance and diverse clinical symptoms.
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Objective: Nonalcoholic fatty liver disease (NAFLD) is considered an independent risk factor for cardiovascular disease (CVD). The overall morbidity and mortality of CVD increase with higher fibrosis stage in NAFLD. Carotid atherosclerosis (CAS) is an important predictor of cardiovascular events.

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  • Volatile chemical products (VCPs) contribute significantly to the presence of volatile organic compounds (VOCs) in urban areas and are important for secondary organic aerosol (SOA) formation.
  • This study focuses on how the evaporation of aerosols from a common room deodorant affects their chemical composition, light absorption, and ability to generate reactive oxygen species (ROS).
  • Results show that aerosol evaporation leads to a concentration of solutes, drastic changes in molecular characteristics, and increased ROS production upon drying, all of which have implications for atmospheric chemistry and climate impact.
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Objective: Endometrial cancer (EC) is a prevalent gynecologic malignancy. The critical role of PTPN18 in EC has been reported, while its role in the aerobic glycolysis of EC cells remains unclear. Our current study focused on the mechanism of PTPN18 in the regulation of aerobic glycolysis in EC.

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  • * Among the 189 cases analyzed, the most common chromosomal abnormality was trisomy 16, with significant CNVs found on chromosomes 4 and 8, linked to genes involved in nervous system development and cell structure.
  • * The research identified 14 potential candidate genes associated with SA, suggesting that certain genetic variations could lead to early pregnancy loss, highlighting the utility of CNV-seq for assessing genetic factors in pregnancies.
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  • This study explores the role of ferroptosis, a type of cell death, as a therapeutic target in treating advanced oral squamous cell carcinoma (OSCC), presenting a comprehensive review of current research on the subject.
  • It highlights the prognostic significance of ferroptosis-related tumor microenvironments, genes, and lncRNAs in OSCC patients, suggesting that these factors can influence patient outcomes.
  • The study also discusses specific interventions that can trigger ferroptosis in OSCC cells, indicating that future therapies aimed at manipulating this process may offer new treatment options for patients.
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Background: Circular RNAs (circRNAs) exhibit unique patterns of expression and high levels of stability in patient plasma samples such that they represent ideal non-invasive biomarkers that can be leveraged to detect a wide array of diseases including endometrial cancer (EC). This study was designed to identify circRNAs with potential diagnostic utility in serum samples from EC patients while also evaluating the utility of macrophage migration inhibitory factor (MIF) as a biomarker when screening for this form of cancer in the clinic.

Methods: Levels of circEPSTI1 and MIF were assessed in the plasma of EC patients and healthy subjects (n=186 each) through qPCR and ELISAs.

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Quercetin is a representative flavonoid that is widely present in fruits, herbs, and vegetables. It is also an important active core component in traditional Chinese medicines. As an important flavonoid, quercetin has various properties and exerts antioxidant, anti-inflammatory, and cardioprotective effects.

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[Retraction to: BMB Rep. 2022 June 30; 55(6): 299-304.] Retraction: "Inhibition of ClC-5 suppresses proliferation and induces apoptosis in cholangiocarcinoma cells through the Wnt/β-catenin signaling pathway," by Zhe Shi, Liyuan Zhou, Yan Zhou, Xiaoyan Jia, Xiangjun Yu, Xiaohong An and Yanzhen Han, BMB Rep.

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  • The study investigates the relationship between time in range (TIR), a glycemic variability index, and metabolic profiles in type 1 diabetes (T1D) patients compared to healthy controls.
  • 85 T1D patients were divided into two groups based on TIR levels, and their serum and urine were analyzed for metabolites using advanced techniques.
  • Results revealed significant differences in metabolites between T1D patients and healthy controls, as well as between subgroups based on TIR, suggesting that certain metabolic pathways may contribute to diabetes complications and warrant further exploration.
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  • Increasing nickel (Ni) content in nickel-based catalysts enhances their activity for the oxygen evolution reaction (OER), addressing challenges in current synthesis methods.
  • A new catalyst, NiS/FeS on FeNi Foam (NiS/FeS@FNF), was developed using anodic electrodeposition, achieving a Ni concentration of 95.02% and significantly reducing NiOOH dissolution.
  • The NiS/FeS@FNF catalyst demonstrated excellent OER performance, with low Tafel slopes and stable operation for 200 hours, indicating its potential for large-scale industrial use.
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Unlabelled: Despite the immense success of immune checkpoint blockade (ICB) in cancer treatment, many tumors, including melanoma, exhibit innate or adaptive resistance. Tumor-intrinsic T-cell deficiency and T-cell dysfunction have been identified as essential factors in the emergence of ICB resistance. Here, we found that protein arginine methyltransferase 1 (PRMT1) expression was inversely correlated with the number and activity of CD8+ T cells within melanoma specimen.

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  • Transfer RNA-derived fragments (tRFs) are small non-coding RNAs implicated in various diseases, but their specific role in cancer has not been fully understood.
  • A study identified a tRF known as CAT1, which is significantly upregulated in multiple cancers, including lung cancer, and is linked to worse patient outcomes.
  • CAT1 enhances NOTCH2 expression by binding to a specific RNA-binding protein, leading to increased lung cancer cell growth and spread, and plasma CAT1 levels are notably higher in lung cancer patients compared to non-cancer individuals.
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  • Metal anodes enhance energy density compared to traditional ion-insertion anodes but face issues like dendrites and corrosion.
  • A new protective layer made of continuous and flexible amorphous Metal-Organic Framework (MOF) successfully reduces dendrite growth and enhances ion migration, outperforming crystalline MOF layers in terms of stability and lifespan.
  • This innovative amorphous MOF layer not only boosts the cycling life of Zn anodes (over 7900 hours) but also benefits other metal anodes (like Mg and Al), showcasing its potential for advanced battery applications.
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