1-Octen-3-ol exacerbates depression-induced neurotoxicity via the TLR4/NF-κB and Nrf2/HO-1 pathways.

1-Octen-3-ol is a volatile compound widely found in various fungi and plants, and studies have suggested its potential role in the development of neurodegenerative diseases. However, the mechanism by which 1-octen-3-ol induces neural injury in rats remains unclear. In this study, we used aerosolized 1-octen-3-ol to treat depressive model rats to investigate its effects on neural injury behaviors and neurophysiology in SD rats.

State-dependent neurovascular modulation induced by transcranial ultrasound stimulation.

Previous studies reported baseline state-dependent effects on neural and hemodynamic responses to transcranial ultrasound stimulation. However, due to neurovascular coupling, neither neural nor hemodynamic baseline alone can fully explain the ultrasound-induced responses. In this study, using a general linear model, we aimed to investigate the roles of both neural and hemodynamic baseline status as well as their interactions in ultrasound-induced responses.

Evaluation of left ventricular systolic function in patients with iron deficiency anemia based on non-invasive left ventricular pressure-strain loops.

Background: Iron deficiency anemia (IDA) is a common health problem worldwide. The objective of this study was to noninvasively and quantitatively evaluate early changes in left ventricular systolic function in patients with IDA using the left ventricular press-strain loop (LV-PSL).

Methods: Sixty-two patients with IDA were selected and divided into two groups based on hemoglobin (Hb) concentration: Group B with Hb > 9 g/dL and group C with 6 g/dL < Hb < 9 g/dL.

Effect of Continuous Infusion of Different Doses of Esketamine on the Bispectral Index During Sevoflurane Anesthesia: A Randomized Controlled Trial.

Purpose: To investigate and quantify the effect of continuous esketamine infusion at different doses on the bispectral index (BIS) during sevoflurane anesthesia.

Methods: A total of 120 patients scheduled for elective laparoscopic renal surgery were randomly divided into three groups. Under steady anesthesia and surgical situations, the patient was started on continuous infusion of the study drug: 0.

The effect of glycopyrrolate vs. atropine in combination with neostigmine on cardiovascular system for reversal of residual neuromuscular blockade in the elderly: a randomized controlled trial.

Background: Glycopyrrolate-neostigmine (G/N) for reversing neuromuscular blockade (NMB) causes fewer changes in heart rate (HR) than atropine-neostigmine (A/N). This advantage may be especially beneficial for elderly patients. Therefore, this study aimed to compare the cardiovascular effects of G/N and A/N for the reversal of NMB in elderly patients.

The brain markers of creativity measured by divergent thinking in childhood: Hippocampal volume and functional connectivity.

Creativity, a high-order cognitive ability, has received wide attention from researchers and educators who are dedicated to promoting its development throughout one's lifespan. Currently, creativity is commonly assessed with divergent thinking tasks, such as the Alternative Uses Task. Recent advancements in neuroimaging techniques have enabled the identification of brain markers for high-order cognitive abilities.

Optimization of regional emergency supplies distribution vehicle route with dynamic real-time demand.

Given the particular characteristics of a sudden outbreak of an epidemic on a regional scale and considering the possible existence of a latent period process, this paper takes the distribution of regional emergency supplies as the research object. Form the proposes a dynamic vehicle path problem from the perspective of real-time demand changes. First, when there is a sudden outbreak of a small-scale epidemic, there is uncertainty about demand in the epidemic area.

Transcranial ultrasound stimulation modulates the interhemispheric balance of excitability in human motor cortex.

. Low-intensity transcranial ultrasound stimulation (TUS) could induce both immediate and long-lasting neuromodulatory effects in human brains. Interhemispheric imbalance at prefrontal or motor cortices generally associates with various cognitive decline in aging and mental disorders.

A multi-center joint distribution optimization model considering carbon emissions and customer satisfaction.

Logistics enterprises are searching for a sustainable solution between the economy and the environment under the concept of green logistics development. Given that, this study integrates carbon emission as one of the costs into the vehicle routing problem with time window (VRPTW) and establishes a multi-center joint distribution optimization model taking into account distribution cost, carbon emission, and customer satisfaction. In the study of carbon emissions, this paper selected the vehicle load rate and vehicle distance as the main indicators.

MiR-7 Regulates Pathogen-Induced Immune Response PAK1 in the Sea Cucumber .

MicroRNA-7 (miR-7) is a highly conserved short non-coding RNA involved in various bioprocesses the regulation of multiple target genes. To enrich our knowledge of the functions of miR-7 in innate immune regulation in echinoderms, we first investigated the targeting relationship between miR-7 and in the sea cucumber and then explored the functions of miR-7, the gene, and the miR-7/ axis in the pathogen-induced immune response of . Our results showed that miR-7 can bind to the 3'UTR of and negatively regulate the expression of in .

Microbiome-Metabolome Responses in Ruminal Content and Feces of Lactating Dairy Cows With N-Carbamylglutamate Supplementation Under Heat Stress.

The objective of the present study was to investigate the effects of N-carbamylglutamate (NCG) supplementation on metabolic profile and microbiota in ruminal content and feces of lactating dairy cows under heat stress (HS). Forty-eight lactating Holstein cows (154 ± 13.6 days in milk) were assigned randomly to four treatments ( = 12), to receive 0, 15, 20, or 25 g/day of commercial NCG (proportion: 97.

Demand forecast and influential factors of cold chain logistics based on a grey model.

Due to high requirements of storage, operation and delivery conditions, it is more difficult for cold chain logistics to meet the demand with supply in the course of disruption. And, accurate demand forecasting promotes supply efficiency for cold chain logistics in a changeable environment. This paper aims to find the main influential factors of cold chain demand and presents a prediction to support the resilience operation of cold chain logistics.

A Constructivist Ontology Relation Learning Method.

From the perspective of philosophy, ontology relations denote ultimate semantic relations of related knowledge concepts. Beyond doubt, it is still a very difficult problem on how to automatically depict and construct ontology relations because of its high abstractness. Some latest research attempted to realize ontology relation learning by learning abstract hierarchies or similarities among knowledge concepts.

Comparative Mitogenomics of Fungal Species in Stachybotryaceae Provides Evolutionary Insights into Hypocreales.

is one of the world's ten most feared fungi within the family Stachybotryaceae, although to date, not a single mitogenome has been documented for Stachybotryaceae. Herein, six mitogenomes of four different species in Stachybotryaceae are newly reported. The mitogenome was 30.

Transcranial ultrasound stimulation of the human motor cortex.

It has been 40 years since the report of long-term synaptic plasticity on the rodent brain. Transcranial ultrasound stimulation (TUS) shows advantages in spatial resolution and penetration depth when compared with electrical or magnetic stimulation. The repetitive TUS (rTUS) can induce cortical excitability alteration on animals, and persistent aftereffects were observed.

Dynamic evolution of eukaryotic mitochondrial and nuclear genomes: a case study in the gourmet pine mushroom Tricholoma matsutake.

Fungi, as eukaryotic organisms, contain two genomes, the mitochondrial genome and the nuclear genome, in their cells. How the two genomes evolve and correlate to each other is debated. Herein, taking the gourmet pine mushroom Tricholoma matsutake as an example, we performed comparative mitogenomic analysis using samples collected from diverse locations and compared the evolution of the two genomes.

Efficient mineralization of gaseous benzyl chloride by VUV/UV photodegradation in humid air.

VUV/UV photodegradation technology, which is free of catalysts or oxidants, has been regarded as an efficient method to decompose gaseous VOCs. However, the mineralization of gaseous VOCs by VUV/UV photodegradation has seldom been discussed systematically. In this work, the mineralization of benzyl chloride in humid air is comprehensively investigated and the potential contributors in the system (i.

Knowledge and attitudes regarding cancer pain management among oncology nurses in China.

Objective: There are limited studies examining knowledge and attitudes among Chinese oncology nurses regarding cancer pain management.

Methods: We conducted a cross-sectional survey among oncology nurses from 26 hospitals in China. The nurses completed the Knowledge and Attitudes Survey Regarding Pain (KASRP) questionnaire.

Relationship between [corrected] spatial memory in diabetic rats and protein kinase Cγ, caveolin-1 in the hippocampus and neuroprotective effect of catalpol.

Background: The mechanisms underlying diabetic encephalopathy are largely unknown, and no effective treatments are available. Catalpol has received much attention due to its numerous biological effects, especially in neuroprotective studies. The aim of this study was to investigate the effects of catalpol on cognitive functions in diabetic rats and the underlying mechanisms.