miR-1224 Controls Mammal Cerebral Cortex Development by Targeting the 3'-UTR of the Dlx1 mRNA.

Neural precursor cells (NPCs) are a group of cells with self-renewal and multi-differentiation potential. MicroRNAs are required for neurogenesis in the central nervous system (CNS). Recent reports suggest that miR-1224 is important in human CNS diseases.

Propagation dynamics of orbital angular momentum beams under the hazy scattering environment.

The disturbance of the scattering medium, such as hazy, can affect the propagation of vortex beams and induce cross-talk within the orbital angular momentum (OAM) spectrum in optical communications based on vortex beams. This paper first validates the integrated scattering phase screen model through experimental beam phase measurements using a simple interferometer. Then, the influence of macroscopic physical parameters of the scattering medium on the OAM spectrum is investigated based on the hazy scattering phase model.

Oxychloride Polyanion Clustered Solid-State Electrolytes via Hydrate-Assisted Synthesis for All-Solid-State Batteries.

Solid-state electrolytes (SSEs) play a vital role in the development of high-energy all-solid-state batteries. However, most adopted mechanical ball milling and/or high-temperature annealing are ineffective approaches for large-scale synthesis. Herein, a universal and scalable hydrate-assisted strategy for the synthesis of oxychloride SSEs is developed based on the chemical reaction among alkali chlorides, AlCl, and AlCl·6HO.

Mediating role of depression in linking rheumatoid arthritis to all-cause and cardiovascular-related mortality: A prospective cohort study.

Objective: This study aimed to analyze the associations between rheumatoid arthritis (RA) and all-cause mortality and cardiovascular disease (CVD)-related mortality using data from the National Health and Nutrition Examination Survey (NHANES) and examine the potential mediating role of depression in these correlations.

Methods: 19,165 participants across five NHANES cycles from 2007 to 2016 participated in this study. Multifactorial Cox regression models between RA, depression and two mortality outcomes and multifactorial regression models between RA and depression were constructed to examine their associations.

Is erectile dysfunction associated with osteoarthritis and rheumatoid arthritis? Insights from a population-based study.

Background: The correlation between osteoarthritis (OA) and rheumatoid arthritis (RA), both significant components of arthritis, and erectile dysfunction (ED) has yet to be thoroughly investigated.

Aim: In this study we aimed to assess the association of OA and RA with ED.

Methods: In this observational study we used data from the National Health and Nutrition Examination Survey, which was conducted between 2001 and 2004.

Is inflammation a missing link between relative handgrip strength with hyperlipidemia? Evidence from a large population-based study.

Background: Relative handgrip strength (RHGS) was positively correlated with healthy levels of cardiovascular markers and negatively correlated with metabolic disease risk. However, its association with hyperlipidemia remains unknown. The present study investigated the link between RHGS and hyperlipidemia, utilizing data from the National Health and Nutrition Examination Survey (NHANES) and further examined the hypothesis that inflammation may serve a mediating role within this relationship.

Association between oxidative balance score and rheumatoid arthritis in female: a cross-sectional study.

Objective: Although oxidative stress is a recognized factor of inflammation, the correlation between oxidative balance score (OBS), a biomarker indicating the balance of oxidation and antioxidant, and rheumatoid arthritis (RA), an immune system disease that tends to occur in women, remains unexplored. Hence, the aim of this study was to investigate the potential association between OBS and RA in women.

Methods: Observational surveys were performed by employing information extracted from the National Health and Nutrition Examination Survey (NHANES) for the period 2007-2018.

Secondary Amines Functionalized Organocatalytic Iodine Redox for High-Performance Aqueous Dual-Ion Batteries.

Aqueous dual-ion batteries (ADIBs) based on the cooperative redox of cations and iodine anions at the anode and cathode respectively, are attracting increasing interest because of high capacity and safety. However, the full-cell performance is limited by the sluggish iodine redox kinetics between iodide and polyiodide involving multiple electron transfer steps, and the undesirable shuttling effect of polyiodides. Here, this work reports a versatile conjugated microporous polymer functionalized with secondary amine groups as an organocatalytic cathode for ADIB, which can be positively charged and electrostatically adsorb iodide, and organocatalyze iodine redox reactions through the amine groups.

The clinical characteristics, gene mutations and outcomes of myelodysplastic syndromes with diabetes mellitus.

Purpose: Diabetes mellitus (DM) is the second most common comorbidity in myelodysplastic syndromes (MDS). The purpose of the study was to investigate the clinical characteristics of MDS patients with DM.

Methods: A retrospective analysis was performed on the clinical data of 890 MDS patients with or without DM.

deficiency impairs HSPC homeostasis and erythropoiesis via and predicts poor prognosis in MDS.

Myelodysplastic syndrome (MDS) is a group of clonal hematopoietic neoplasms originating from hematopoietic stem progenitor cells (HSPCs). We previously identified frequent roundabout guidance receptor 1 () mutations in patients with MDS, while the exact role of in hematopoiesis remains poorly delineated. Here, we report that deficiency confers MDS-like disease with anemia and multilineage dysplasia in mice and predicts poor prognosis in patients with MDS.

BER performance of an FSOC system over atmospheric turbulence channels based on computational temporal ghost imaging.

In a free space optical communication (FSOC) system, atmospheric turbulence will increase the bit error ratio (BER) and impair FSOC link reliability. Since computational temporal ghost imaging (CTGI) has anti-interference, we present an FSOC system over atmospheric turbulence based on CTGI. The simulation results show that the BER performance of CTGI is better than on-off keying under different atmospheric turbulence regimes.

The association between triglyceride glucose index and arthritis: a population-based study.

Objectives: Insulin resistance is a well-established contributor to inflammation; however, the specific association between the triglyceride glucose (TyG) index, a biomarker reflecting insulin resistance, and arthritis remains unexplored. As a result, the main aim of this study was to examine the correlation between the TyG index and arthritis.

Methods: This observational study used data from the National Health and Nutrition Examination Survey (NHANES), which was conducted between 2007 and 2018.

Maximizing Electrostatic Polarity of Non-Sacrificial Electrolyte Additives Enables Stable Zinc-Metal Anodes for Aqueous Batteries.

Although additives are widely used in aqueous electrolytes to inhibit the formation of dendrites and hydrogen evolution reactions on Zn anodes, there is a lack of rational design principles and systematic mechanistic studies on how to select a suitable additive to regulate reversible Zn plating/stripping chemistry. Here, using saccharides as the representatives, we reveal that the electrostatic polarity of non-sacrificial additives is a critical descriptor for their ability to stabilize Zn anodes. Non-sacrificial additives are found to continuously modulate the solvation structure of Zn ions and form a molecular adsorption layer (MAL) for uniform Zn deposition, avoiding the thick solid electrolyte interphase layer due to the decomposition of sacrificial additives.

The Diagnostic Accuracy of Different MRI Sequences for Different Meniscus Lesions: A Meta-analysis.

Background: It is still uncertain to determine the exact diagnostic accuracy of MRI for medial meniscus (MM) tear, lateral meniscus (LM) tear and MM posterior root tear (MMPRT) at different magnetic field intensities (MFIs), different sequences and different publication dates. This study aimed to identify the diagnostic performance of MRI for different meniscus lesions at different MFIs, different sequences and different publication dates, and also to compare it with physical examination.

Methods: PubMed, Embase, Ovid database, Biosis Previews, Cochrane library, Web of Sciences and manual searching were performed from 1 January 2000 to 31 December 2021.

Cognitive control of invalid predominant ideas in insight-like problem solving.

Predominant ordinary ideas are insufficient for solving insight-like problems; they interfere with subordinate original ideas and can produce a mental impasse. However, how people monitor and control invalid predominant ideas remains largely unknown. In the current study, participants were asked to solve a sequence of several similar practice problems that had the same solution to strengthen a predominant idea; the participants were then presented with an insight-like test problem that could not be solved by the predominant idea.

Expectations Attenuate the Negative Influence of Neural Adaptation on the Processing of Novel Stimuli: ERP Evidence.

When processing repeated stimuli, the neural response is attenuated (i.e., neural adaptation) and performance seems to be facilitated; however, this neural adaptation negatively influences the subsequent processing of novel stimuli.

Microstructure and Phase Evolution Characteristics of the In Situ Synthesis of TiC-Reinforced AZ91D Magnesium Matrix Composites.

TiC-reinforced AZ91D magnesium alloy composites were synthesized through the in situ reaction between an AZ91D melt and Ti-C-Al preforms. The microstructural evolution characteristics and phase transformation were investigated at different melt reaction temperatures (1013, 1033, and 1053 K), with the aim of understanding the in situ formation mechanism of TiC particles from thermodynamic and kinetic perspectives. The results showed that the temperature played a critical role in determining the formation and morphology of TiC.

Improving the signal-to-noise ratio of computational ghost imaging of a reflective object with a rough surface by Hadamard modulated light field.

We propose an optimization scheme to improve the reconstruction quality of computational ghost imaging (GI) of a reflective target with a rough surface by using the Hadamard modulation light field (HCGI). By comparison with computational GI with a traditional Gaussian light field (GCGI), the signal-to-noise ratio of GCGI is quite bad, and it is difficult to distinguish the imaging signal from the background when the surface roughness of the object is higher, while a ghost image with better quality can be obtained by HCGI. The difference is explained by comparing the distribution of the correlation coefficient.

Dynamics of epigenetic regulator gene BCOR mutation and response predictive value for hypomethylating agents in patients with myelodysplastic syndrome.

Background: BCOR (BCL6 corepressor) is an epigenetic regulator gene involved in the specification of cell differentiation and body structure development. Recurrent somatic BCOR mutations have been identified in myelodysplastic syndrome (MDS). However, the clinical impact of BCOR mutations on MDS prognosis is controversial and the response of hypomethylating agents in MDS with BCOR mutations (BCOR) remains unknown.

Alisol B 23-acetate, a new promoter for cholesterol efflux from dendritic cells, alleviates dyslipidemia and inflammation in advanced atherosclerotic mice.

Atherosclerosis (AS) is characterized by dyslipidemia and chronic inflammation. In the high-fat environment, the lipid metabolism of dendritic cells (DCs) is abnormal, which leads to abnormal immune function, promotes the occurrence of immune inflammatory reactions, and promotes the development of AS. Alisol B 23-acetate (23B) is a triterpenoid in the rhizomes of Alisma, which is a traditional Chinese medicine.

Immune metabolism: a bridge of dendritic cells function.

An increasing number of researches have shown that cell metabolism regulates cell function. Dendritic cells (DCs), a professional antigen presenting cells, connect innate and adaptive immune responses. The preference of DCs for sugar or lipid affects its phenotypes and functions.

Inhibition of PTEN activity promotes IB4-positive sensory neuronal axon growth.

Traumatic nerve injuries have become a common clinical problem, and axon regeneration is a critical process in the successful functional recovery of the injured nervous system. In this study, we found that peripheral axotomy reduces PTEN expression in adult sensory neurons; however, it did not alter the expression level of PTEN in IB4-positive sensory neurons. Additionally, our results indicate that the artificial inhibition of PTEN markedly promotes adult sensory axon regeneration, including IB4-positive neuronal axon growth.

Resveratrol ameliorates atherosclerosis induced by high-fat diet and LPS in ApoE mice and inhibits the activation of CD4 T cells.

Background: Atherosclerosis (AS), which characterized with the accumulation of lipids on the vessel wall, is the pathological basis of many cardiovascular diseases (CVD) and seriously threatens human health. Resveratrol (RES) has been reported to be benefit for AS treatment. This research aimed to observe the effects of RES on AS induced by high-fat diet (HFD) and LPS in ApoE mice and investigate the underlying mechanism.