Effective Solution toward the Issues of Zn-Based Anodes for Advanced Alkaline Ni-Zn Batteries.

Alkaline nickel-zinc (Ni-Zn) batteries, as traditional rechargeable aqueous batteries, possess an obvious advantage in terms of energy density, but their development has been hindered by the anode-concerned problems, Zn dendrites, self-corrosion, passivation, deformation, and hydrogen evolution reaction (HER). Herein, to solve these problems, a dual protective strategy is proposed toward the anode using ZnO as an initial active material, including a C coating on ZnO (ZnO@C) and a thin poly(vinyl alcohol) (PVA) layer coating on the electrode (ZnO@C-PVA). In a three-electrode configuration, the reversible capacity can reach 600 mAh g for the ZnO@C-PVA.

LncPTSR Triggers Vascular Remodeling in Pulmonary Hypertension by Regulating [Ca] in Pulmonary Arterial Smooth Muscle Cells.

Pulmonary hypertension (PH) is characterized by vascular remodeling and sustained increase in right ventricular systolic pressure. The molecular mechanisms behind PH development remain unclear. Here, a long noncoding RNA (lncRNA) attenuated by platelet-derived growth factor BB (PDGF-BB) was identified, and its functional roles were investigated and .

PDGF/MEK/ERK axis represses Ca clearance via decreasing the abundance of plasma membrane Ca pump PMCA4 in pulmonary arterial smooth muscle cells.

Pulmonary arterial hypertension (PAH) is a rare and lethal disease characterized by vascular remodeling and vasoconstriction, which is associated with increased intracellular calcium ion concentration ([Ca]). Platelet-derived growth factor-BB (PDGF-BB) is the most potent mitogen for pulmonary arterial smooth muscle cells (PASMCs) and is involved in vascular remodeling during PAH development. PDGF signaling has been proved to participate in maintaining Ca homeostasis of PASMCs; however, the mechanism needs to be further elucidated.

Association of Controlling Nutritional Status Score With 2-Year Clinical Outcomes in Patients With ST Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention.

Background: This study evaluated whether the Controlling Nutritional Status (CONUT) score could predict clinical outcomes in ST elevation myocardial infarction (STEMI) patients.

Methods: We performed a retrospective cohort study of STEMI patients after primary percutaneous coronary intervention (pPCI). The endpoint was major adverse cardiac event (MACE).

Withdrawal of oral anticoagulants 3 months after successful radiofrequency catheter ablation in patients with atrial fibrillation: A meta-analysis.

Background: The best anticoagulation therapy for atrial fibrillation (AF) after radiofrequency catheter ablation (RFCA) remains a challenge.

Methods: A systematic search of PubMed, Ovid, and Cochrane Library was conducted identifying at clinical trials which evaluated the differences between thromboembolism (TE) and hemorrhage in an off-oral anticoagulants (OACs) treatment group (the observation group) and an on-OACs treatment group (the control group), at 3 months after successful RFCA. Meta-analysis was performed using RevMan 5.

Enhanced degradation of haloacid by heterologous expression in related Burkholderia species.

Haloacids are environmental pollutant and can be transformed to non-toxic alkanoic acids by microbial dehalogenase. Bacterium Burkholderia species MBA4 was enriched from soil for its ability to bioremediate haloacids such as mono-chloroacetate (MCA), mono-bromoacetate (MBA), 2-mono-chloropropionate, and 2-mono-bromopropionate. MBA4 produces an inducible dehalogenase Deh4a that catalyzes the dehalogenation process.