Study of fluoroquinolones resistance in rifampicin-resistant tuberculosis patients in Beijing: Characteristics, trends, and treatment outcomes.

Background: China is a high-burden country for multidrug-resistant tuberculosis/rifampin-resistant tuberculosis (MDR/RR-TB). Fluoroquinolones (FQs) are key drugs for the treatment of patients with MDR/RR-TB. However, research on the resistance of FQs in Beijing is limited.

Appendicoscopy using single-operator cholangioscope in the management of acute obstructive appendicitis: a novel alternative (with video).

Background And Aims: The aim of this study was to investigate the safety and efficacy of appendicoscopy using a single-operator cholangioscope (SOC) for the management of acute obstructive appendicitis.

Methods: This study describes 110 cases of acute obstructive appendicitis managed with the use of appendicoscopy between January 2021 and June 2023. The success rate (technical + clinical), procedure time, time to abdominal pain relief according to a visual analog scale score, postoperative length of hospital stay, and adverse event rates were recorded and analyzed.

Single-operator cholangioscopy system for management of acute cholecystitis secondary to choledocholithiasis.

This study aimed to investigate the safety and efficacy of endoscopic retrograde cholangiopancreatography (ERCP) + EyeMax (single-operator cholangioscopy system; SOC) (i.e., ERCP+SOC) for the treatment of choledocholithasis-associated acute cholecystitis.

Regularized Spectral Spike Response Model: A Neuron Model for Robust Parameter Reduction.

The modeling procedure of current biological neuron models is hindered by either hyperparameter optimization or overparameterization, which limits their application to a variety of biologically realistic tasks. This article proposes a novel neuron model called the Regularized Spectral Spike Response Model (RSSRM) to address these issues. The selection of hyperparameters is avoided by the model structure and fitting strategy, while the number of parameters is constrained by regularization techniques.