Publications by authors named "Liying Li"

The Citri Reticulatae Pericarpium (CRP), is the aged peel of Citrus fruit, which contains phenols, flavonoids, and polysaccharides. This study aims to investigate dietary CRP supplementation on the growth performance, serum biochemical indices, meat quality, intestinal morphology, microbiota, and metabolite of yellow-feathered broilers. A total of 240 yellow-feathered broilers (1.

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It is well known that the function of granulosa cells (GCs) is closely related to follicular development, and and histone methylation have been implicated in follicular development. However, the specific mechanisms by which and histone methylation regulate follicular development are still largely unknown. To explore the specific mechanism of in regulating follicular development, in this study, we showed that the expression of in immature ovaries and small follicles was significantly higher than in mature ovaries and large follicles of sows, respectively.

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Objective: To investigate the correlation between uric acid (UA), urinary protein (UP) and umbilical artery blood flow related parameters and maternal and infant prognosis in patients with hypertensive disorder complicating pregnancy (HDP).

Methods: A total of 110 hDP patients who underwent prenatal examination and delivered in our hospital from June 2018 to May 2023 were selected as the HDP group. According to the prognosis of mother and infant, they were divided into normal prognosis group (n=80) and poor prognosis group (n=30).

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Background: Obstructed labor (OL) and uterine rupture (UR) are common obstetric complications. This study explored the burden, risk factors, decomposition, and health inequalities associated with OL and UR to improve global maternal health.

Methods: This was a cross-sectional analysis study including data on OL and UR from the Global Burden of Diseases, and Risk Factors Study (GBD) 2019.

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Objective: To explore the complications and pregnancy outcomes of vaginal dinoprostone vs. Cook's double balloon for the induction of labor among pregnancies complicated by small-for-gestational-age (SGA) at term.

Methods: This retrospective study included consecutive singleton pregnancies complicated by SGA treated at Fujian Maternity and Child Health Hospital between January 2017 and December 2021.

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Hypertension is one of the most common chronic diseases in older people, and the prevalence is on the rise as the global population ages. Hypertension is closely associated with many adverse health outcomes, including cardiovascular disease, chronic kidney disease and mortality, which poses a substantial threat to global public health. Reasonable blood pressure (BP) management is very important for reducing the occurrence of adverse events.

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Fatty liver, which is induced by abnormal lipid metabolism, is one of the most common causes of chronic liver disease globally and causes liver fibrosis. During this process, bone marrow-derived mesenchymal stromal cells (BMSCs) and hepatic stellate cells (HSCs) migrate toward the injured liver and participate in fibrogenesis by transdifferentiating into myofibroblasts. S100A8/A9 is a powerful inducer of cell migration and is involved in liver injury.

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Article Synopsis
  • Adoptive cellular therapy (ACT) using memory-like natural killer (NK) cells activated with specific cytokines shows promise in treating blood cancers, especially when combined with new fusion molecules.
  • The multifunctional fusion molecule HCW9206 improves the expansion of NK cells that have been primed with another molecule (HCW9201), leading to a significant increase in their quantity and activity.
  • The "Prime and Expand" strategy enhances NK cell metabolism and durability, making it a more efficient method for preparing clinical-grade NK cells for future cancer treatments.
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Background: Hypertension and frailty often coexist in older people. The present study aimed to evaluate the association of frailty status with overall survival in elderly hypertensive patients, using data from the Chinese Longitudinal Healthy Longevity Survey.

Methods: A total of 10,493 elderly hypertensive patients were included in the present study (median age 87.

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The synergism of host Paris polyphylla medium, the monoculture, and the coculture led to seventeen new metabolites, including eight sesquiterpenes, 1-7 having uncommon structural motifs compared to similar caryophyllene derivatives, 8 with an unprecedented bicyclic framework, and three xyloketals (13-15) with unprecedented frameworks from Nigrospora lacticolonia; one polyketide, 17 with novel bicyclo [2.2.2] undecane skeleton, and five polyketide-terpenoid hybrids, 20 (one novel sulfated), 21-24 from Penicillium rubens.

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Procollagen-lysine 2-oxoglutarate 5-dioxygenase 2 (Plod2) is a key collagen lysyl hydroxylase mediating the formation of collagen fiber and stabilized collagen cross-links, and has been identified in several forms of fibrosis. However, the potential role and regulatory mechanism of Plod2 in liver fibrosis remain unclear yet. Mouse liver fibrosis models were induced by injecting carbon tetrachloride (CCl) intraperitoneally.

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Finite, atom-centered Slater basis sets are used to determine approximate Kohn-Sham molecular orbitals. This is achieved by minimizing the kinetic energy plus the sum-squared difference between the Kohn-Sham density and the full configuration interaction density. As a result of the finite basis, a weight factor is introduced to balance the two minimization components.

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Triple-negative breast cancer (TNBC) has attracted attention due to its poor prognosis and limited treatment options. The mechanisms underlying the association between circular RNAs (circRNAs) and the occurrence and development of TNBC remain unclear. CircZCCHC2 is observed to be upregulated in TNBC cells, tissues, and plasma exosomes.

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Article Synopsis
  • The study investigates how changes in frailty status affect all-cause mortality and cardiovascular deaths in older adults using data from the Chinese Longitudinal Healthy Longevity Survey.
  • It analyzes data from 2,805 participants over two time periods (2011 and 2014) and categorizes them into four frailty status groups to determine the associated risks.
  • Results show that individuals who improved in frailty status had significantly lower mortality rates, especially those who maintained robustness, highlighting the importance of frailty transitions in health outcomes for older populations.
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  • The study aimed to examine how the duration of disability in activities of daily living (ADL) affects overall survival in older adults.
  • A total of 15,332 participants were involved, with assessments of ADL disability conducted using the Katz index scale, which evaluates essential daily tasks.
  • Results showed that longer durations of ADL disability led to significantly lower survival rates, particularly in the first year, highlighting the importance of early intervention for older adults with such disabilities.*
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Background: Albumin to fibrinogen ratio (AFR), a new inflammatory marker, has emerged as a useful indicator to predict adverse outcomes for several diseases. However, whether AFR could be a new useful indicator to predict mortality in HCM patients remains to be evaluated. The study explored the predictive value of AFR for HCM-related death in adult HCM patients.

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Healthy Kupffer cell (KC) pool is dominated by embryonic KCs (EmKCs), preserving liver homeostasis. How the KC pool varies upon injury remains unclear. Using chimeric mice with bone marrow (BM) cells labeled with enhanced green fluorescent protein, we identify that BM monocyte-derived KCs (MoKCs) become dominant in cholestatic- or toxic-injured livers via immunofluorescence and mass cytometry.

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Introduction: Mindfulness reflects attention to the present moment in a non-judgmental way and has been linked to individual autonomy and motivation, but conclusions are inconsistent. The purpose of this review was to summarize previous studies to explore the relationship between mindfulness and motivation and its intervention effects.

Methods: Literature searches were conducted in five electronic databases.

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Following the publication of this article, a concerned reader drew to our attention that in Fig. 5C on p. 1704, showing histological images of mouse livers stained with H&E, unexpected areas of similarity were identified in terms of the staining patterns revealed within the data panels themselves.

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15-deoxy-Δ-prostaglandin J (15d-PGJ) exhibited potential to alleviate liver inflammation in chronic injury but was less studied in acute injury. Acute liver injury was associated with elevated macrophage migration inhibitory factor (MIF) levels in damaged hepatocytes. This study aimed to investigate the regulatory mechanism of hepatocyte-derived MIF by 15d-PGJ and its subsequent impact on acute liver injury.

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Introduction: This study aims to explore the mortality risk in older people who drank alcohol in the past by varying the duration of alcohol abstention.

Methods: In total, 31,999 participants aged ≥65 years from the Chinese Longitudinal Healthy Longevity Survey (Waves 1998, 2000, 2002, 2005, 2008, 2011, 2014) were included. Duration of alcohol abstention was assessed by designed questions, and the study outcome was all-cause mortality.

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Article Synopsis
  • Hepatic macrophages, particularly a subgroup called scar-associated macrophages (SAMs), are crucial in the development of liver fibrosis.
  • Research using animal models showed that SAMs originate from bone marrow-derived macrophages and have a significant role in promoting fibrosis by expressing specific pro-fibrotic genes.
  • The transformation of these SAMs is influenced by the interaction of plasminogen receptor (Plg-R) and plasminogen (PLG), indicating that targeting this pathway may offer new treatment strategies for liver fibrosis.
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Objective: A new inflammatory marker, namely monocyte-to-high-density lipoprotein cholesterol ratio (MHR), has emerged as a useful indicator for adverse outcomes in several cardiovascular diseases; however, the relationship between MHR and the prognosis of hypertrophic cardiomyopathy (HCM) remains to be evaluated. We examined the relationship between MHR and all-cause mortality (ACM) in Chinese adult patients with HCM.

Methods: We retrospectively performed clinical evaluation in 305 patients with HCM (median age: 52.

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Synopsis of recent research by authors named "Liying Li"

  • - Liying Li's recent research encompasses diverse aspects of health and medical science, with a focus on maternal health, chronic diseases in aging populations, and cellular therapies for cancer treatment.
  • - Notable studies include an analysis of the global burden of maternal obstructed labor and uterine rupture, as well as research on hypertension in frail older adults, emphasizing the importance of blood pressure management in this vulnerable group.
  • - Li's work also investigates the mechanisms of liver fibrosis and the development of memory-like natural killer cells for cancer immunotherapy, revealing potential therapeutic strategies in managing chronic liver disease and enhancing adoptive cellular therapies.*

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