Genotype-Phenotype Correlations in SYNGAP1-Related Mental Retardation Type 5.

Variants in the SYNGAP1 gene leading to decreased SynGAP protein expression are critical for the pathogenesis of mental retardation type 5 (MRD5). This study aims to explore the relationship between SYNGAP1 genotype and clinical phenotype through an expanded sample size, thereby enhancing the understanding of the specific mechanisms underlying MRD5. Data from previously published cases of patients with SYNGAP1 mutations were collected, and the relationship between genotype and clinical phenotype was analyzed.

Metformin reduces proteinuria in spontaneously hypertensive rats by activating the HIF-2α-VEGF-A pathway.

Metformin has protective effects on diabetic nephropathy. However, the mechanism underlying the renoprotective action of metformin in spontaneously hypertensive rats (SHR) is not completely understood. We determined the role of metformin in proteinuria and investigated the mechanism.

Effect of correlated colour temperature and illuminance levels on user's visual perception under LED lighting in Taiwan.

This study aimed to utilise the characteristics of light-emitting diode (LED) lighting, including the adjustable correlated colour temperature (CCT) and illuminance levels, to evaluate the effects of various CCT and illuminance level combinations on visual perception and their patterns under different lighting conditions. Five white light balances with different CCTs were created together with four levels of illuminance. Based on the patterns of visual perception, when the CCT increased with the illuminance levels, the participants' visual perception changed from dim, boring, and sleepy to intense, vivid, energetic, and bright.

Sensitivity Enhancement of Transition Metal Dichalcogenides/Silicon Nanostructure-based Surface Plasmon Resonance Biosensor.

In this work, we designed a sensitivity-enhanced surface plasmon resonance biosensor structure based on silicon nanosheet and two-dimensional transition metal dichalcogenides. This configuration contains six components: SF10 triangular prism, gold thin film, silicon nanosheet, two-dimensional MoS2/MoSe2/WS2/WSe2 (defined as MX2) layers, biomolecular analyte layer and sensing medium. The minimum reflectivity, sensitivity as well as the Full Width at Half Maximum of SPR curve are systematically examined by using Fresnel equations and the transfer matrix method in the visible and near infrared wavelength range (600 nm to 1024 nm).

The non-aqueous synthesis of shape controllable Cu(2-x)S plasmonic nanostructures in a continuous-flow millifluidic chip for the generation of photo-induced heating.

In this paper, a new method for synthesizing non-aqueous copper sulfide nanocrystals with different shapes and sizes using a homemade continuous-flow millifluidic chip is presented. Conventionally, the shape control of nanocrystals was accomplished using a surfactant-controlled approach, where directional growth is facilitated by selective passivation of a particular facet of the nanocrystals using surfactants. We demonstrate a "surfactant-free" approach where different sizes and shapes (i.