Verifying the Equivalence of Hawthorn Leaves Standard Decoction and Formula Granules by LC-MS and Oxidative Stress Test.

Objective: To verify the equivalence of hawthorn leaves standard decoction and formula granules.

Methods: In this experiment, liquid chromatograph mass spectrometer (LC-MS) was used to examine the chemical composition of hawthorn leaves standard decoction and formula granules, separately. In addition, oxidative stress test was used to explore the antioxidant capacity of them.

Exploring the mechanism of aloe-emodin in the treatment of liver cancer through network pharmacology and cell experiments.

Aloe-emodin (AE) is an anthraquinone compound extracted from the rhizome of the natural plant rhubarb. Initially, it was shown that AE exerts an anti-inflammatory effect. Further studies revealed its antitumor activity against various types of cancer.

Exploring the mechanism of curcumin in the treatment of colon cancer based on network pharmacology and molecular docking.

Curcumin is a plant polyphenol extracted from the Chinese herb turmeric. It was found that curcumin has good anti-cancer properties in a variety of cancers, but the exact mechanism is not clear. Based on the network pharmacology and molecular docking to deeply investigate the molecular mechanism of curcumin for the treatment of colon cancer, it provides a new research direction for the treatment of colon cancer.

High-throughput LC-MS method for the rapid characterisation and comparative analysis of multiple ingredients of four hawthorn leaf extracts.

Introduction: The comprehensive component characterisation of Chinese herbal medicine is the premise of effectively driving the discovery of pharmacodynamic substances or new drugs in recent years.

Objective: To use the high-throughput liquid chromatography-mass spectrometry (LC-MS) approach to systematically characterise phytochemical compounds from four hawthorn leaf extracts, along with evaluating their classification.

Methods: In the present study, the compounds from 50% ethanol extract, macro porous resin extract, ethyl acetate extract and standard decoction of hawthorn leaves were completely analysed by ultrahigh-performance liquid chromatography-quadrupole time-of-flight tandem mass spectrometry (UPLC-Q-TOF-MS).

UPLC-Q-TOF-MS based metabolomics study of hawthorn leaves in different geographical regions.

The quality evaluation of hawthorn leaves in different geographical regions derived from the dried leaves of Bge. Var. Major N.

Gypenoside XVII protects against spinal cord injury in mice by regulating the microRNA‑21‑mediated PTEN/AKT/mTOR pathway.

Gypenoside XVII (GP‑17), one of the dominant active components of , has been studied extensively and found to have a variety of pharmacological effects, including neuroprotective properties. However, the neuroprotective effects of GP‑17 against spinal cord injury (SCI), as well as its underlying mechanisms of action remain unknown. The present study aimed to investigate the effects of GP‑17 on motor recovery and histopathological changes following SCI and to elucidate the mechanisms underlying its neuroprotective effects in a mouse model of SCI.

Synthesis, crystal structure, and photochromism of novel two-dimensional supramolecular networks based on Keggin-type polyoxoanion and lanthanide coordination cations.

Three new compounds [Ln(NMP)(4)(H(2)O)(4)][H(x)()GeMo(12)O(40)].2NMP.3H(2)O (Ln = Ce(IV) (1), Pr(IV) (2), x = 0; Ln = Nd(III) (3), x = 1; NMP = N-methyl-2-pyrrolidone) have been prepared in aqueous solution and characterized by elemental analyses, IR, UV-vis, and TG analyses.