Iron(III) and BF·OEt-Promoted O-Transfer Reaction of -Aryl-α,β-Unsaturated Nitrones to Prepare Difluoroboron β-Ketoiminates.

We described an iron(III) and BF·OEt-promoted oxygen transfer reaction of -aryl-α,β-unsaturated nitrones to prepare various ,-difluoroboron β-ketoiminates in good yields ranging from 24% to 87%. Control experiments revealed that the enaminone was the vital intermediate for the formation of ,-difluoroboron β-ketoiminates, and iron(III) combined with BF·OEt played as cocatalyst to promote the oxygen transfer reaction through intramolecular cyclization and N-O bond cleavage. More importantly, an estrone-derived ,-difluoroboron β-ketoiminate was easily prepared in 40% yield from estrone in four steps.

Combined Dextran-Graft-Polyacrylamide/Zinc Oxide Nanocarrier for Effective Anticancer Therapy in vitro.

Introduction: Cancer chemotherapy faces two major challenges - high toxicity of active substances and tumor resistance to drugs. Low toxic nanocarriers in combination with anticancer agents can significantly increase the effectiveness of therapy. Modern advances in nanotechnology make it easy to create materials with the necessary physical and chemical properties.