A novel proprioceptive rehabilitation program: A pilot randomized controlled trail as an approach to address proprioceptive deficits in patients with diabetic polyneuropathy.

Background: Diabetic polyneuropathy (DPN) is a notable microvascular complication of DM, affecting 16%-66% globally. DPN often leads to proprioceptive deficits in the lower limbs (LL), leading to impaired functional performance. However, evidence supporting proprioceptive rehabilitation programs (PRP) for DPN remains scarce.

Manual and ventilator hyperinflation parameters used by intensive care physiotherapists in Sri Lanka: An online survey.

Introduction: Hyperinflation is a common procedure to clear secretion, increase lung compliance and enhance oxygenation in mechanically ventilated patients. Hyperinflation can be provided as manual hyperinflation (MHI) or ventilator hyperinflation (VHI), where outcomes depend upon the methods of application. Hence it is crucial to assess the application of techniques employed in Sri Lanka due to observed variations from recommended practices.

Effects of Different Physical Therapy Interventions in Improving Flexibility in University Students with Hamstring Tightness - A Systematic Review and Network Meta-analysis.

Unlabelled: The aim of the present study was to identify the different interventions for hamstring flexibility among university students with hamstring tightness and to determine the better treatment method.

Design: Systematic review and network meta-analysis. An electronic search of the databases: Medline, Pubmed, Cochrane, EMBASE, CINAHL, Physiotherapy Evidence Database (PEDro) was conducted.

Prevalence of falls and comparison of health-related physical fitness factors between different faller categories among institutionalized older adults in Kandy District of Sri Lanka.

Falls can be identified as one of the main issues in elderly population which can lead to serious consequences. Elderly population can be subdivided as community dwelling older adults and institutionalized older adults. The components of health-related physical fitness factors play an important role in the perspective of healthy ageing.

Pharmacological rescue of mitochondrial and neuronal defects in hereditary spastic paraplegia patient neurons using high throughput assays.

is the most common form of autosomal recessive hereditary spastic paraplegia (HSP). There is a lack of HSP- human neuronal models to understand the disease mechanism and identify new drug treatments. We generated a human neuronal model of HSP- using induced pluripotent stem (iPS) cell technology.

Sinhala version of the Cornell Musculoskeletal Discomfort Questionnaire: Cross-cultural adaptation and validation.

Background: Work-related musculoskeletal disorders (WMSDs) are highly prevalent among people who work in sedentary jobs. The Cornell Musculoskeletal Discomfort Questionnaire (CMDQ) is a valid tool to assess WMSDs, but is not available in the local language of Sri Lanka (Sinhala).

Objective: To cross-culturally adapt the original CMDQ from English to Sinhala and evaluate its psychometric properties.

Reduced acetylated α-tubulin in hereditary spastic paraplegia patient PBMCs.

HSP is the most common form of hereditary spastic paraplegia (HSP), a neurodegenerative disease causing lower limb spasticity. Previous studies using HSP patient-derived induced pluripotent stem cell cortical neurons have shown that patient neurons have reduced levels of acetylated α-tubulin, a form of stabilized microtubules, leading to a chain of downstream effects eventuating in increased vulnerability to axonal degeneration. Noscapine treatment rescued these downstream effects by restoring the levels of acetylated α-tubulin in patient neurons.

Mitochondrial Function in Hereditary Spastic Paraplegia: Deficits in but Not Patient-Derived Stem Cells.

Mutations in and are common causes of hereditary spastic paraplegia (HSP). While some mutations cause paraplegin deficiency, other mutations cause increased paraplegin expression. Mitochondrial function has been studied in models that are paraplegin-deficient (human, mouse, and models with large exonic deletions, null mutations, or knockout models) but not in models of mutations that express paraplegin.

Oxidative Stress-Induced Axon Fragmentation Is a Consequence of Reduced Axonal Transport in Hereditary Spastic Paraplegia Patient Neurons.

Hereditary spastic paraplegia (HSP) is a group of inherited disorders characterized by progressive spasticity and paralysis of the lower limbs. Autosomal dominant mutations in gene account for ∼40% of adult-onset patients. We have previously shown that patient cells have reduced organelle transport and are therefore more sensitive to oxidative stress.

Unusual case of recurrent thigh lump in a girl: a case report.

Introduction: Lipofibromatosis is a rare fibro-fatty tumour with a predilection to involve distal extremities. It has only recently been described as a distinctive clinicopathologic entity, and subsequently only a few cases have been published in the literature. To address the clinicopathologic significance of this rare entity, we here describe a case of lipofibromatosis occurring on the left thigh of a Sri Lankan girl who developed a recurrence following excision.